Fetal Cardiac Surgery

Fetal cardiac surgery is prenatal intervention for selected congenital heart defects, performed before birth to alter disease progression and improve outcomes after delivery. In commonly used catheter-based procedures, clinicians guide a needle and balloon catheter through the mother’s abdomen and uterus into the fetal heart under ultrasound, then dilate a critically narrowed aortic or pulmonary valve to restore forward blood flow. These interventions may support ventricular growth and preserve treatment options that would otherwise be limited at birth. Because procedures involve maternal, fetal, and placental risks, they require careful imaging, multidisciplinary planning, and specialized expertise in fetal and pediatric cardiology.

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Research

JoVE Journal - Medicine

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction

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Cited by 11 •

2013

We describe examination of fetal cardiac function with contemporary functional fetal echocardiography and fetoplacental Doppler ultrasound using the VisualSonics VEVO 2100 microultrasound in a surgically induced model of intrauterine fetal growth restriction in a rabbit.

Murine Fetal Echocardiography

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Cited by 7 •

2013

Fetal and perinatal death is a common feature when studying genetic alterations affecting cardiac development. High-frequency ultrasound imaging has improved 2-D resolution and can provide excellent information on early cardiac development and is an ideal method to detect the impact on cardiac structure and function prior to death.

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

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Cited by 9 •

2017

Endothelial progenitor cells (EPCs) are crucially involved in the neovascularization of ischemic tissues. This method describes the isolation of human EPCs from peripheral blood, as well as the identification of their migratory potential against serum samples of cardiac surgical patients.

A Mouse Fetal Skin Model of Scarless Wound Repair

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Cited by 24 •

2015

During mammalian development, early gestational skin wounds heal without a scar. Here we detail a reliable and reproducible model of fetal scarless wound healing in the cutaneous dorsum of E16.5 (scarless) and E18.5 (scarring) mouse embryos.

Transuterine Fetal Tracheal Occlusion Model in Mice

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Cited by 2 •

2021

Various animal models of congenital diaphragmatic hernia and fetal tracheal occlusion present advantages and disadvantages regarding ethical issues, cost, surgical difficulty, size, survival rates, and availability of genetic tools. This model provides a new tool to study the impact of both tracheal occlusion and increased luminal pressure on lung development.

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