Ascending Aortic Flow
Ascending Aortic Flow - Related Videos
10:18
Ascending Aortic Constriction in Rats for Creation of Pressure Overload Cardiac Hypertrophy Model
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Cited by 17 •
2014
We describe a stepwise procedure for creating pressure overload and left ventricular hypertrophy in Wistar rats by constriction of the ascending aorta using a small metallic clip. This model is extensively used for studying remodeling changes during cardiac hypertrophy and for identifying and evaluating strategies for regression of such changes.
10:08
Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound
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Cited by 10 •
2014
We describe a technique for measuring aortic stiffness from its pressure-diameter relationship in vivo in mice. Aortic diameter is recorded by ultrasound and aortic pressure is measured invasively with a solid-state pressure catheter. Blood pressure is changed incrementally and the resulting diameter is measured.
09:12
Aortic Ring Assay
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Cited by 42 •
2009
Angiogenesis, the sprouting of blood vessels from pre-existing vasculature, is associated with both natural and pathological processes. Here we demonstrate an aortic ring assay that allows angiogenic potentiators and inhibitors to be directly added to aortic rings in culture. Sprouting and neovessel outgrowth can be determined by inspecting the aortic rings over a period of 6-12 days.
07:40
Minimally Invasive Transverse Aortic Constriction in Mice
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Cited by 42 •
2017
Minimally invasive transverse aortic constriction (MTAC) conserves the essentials of regular transverse aortic constriction (TAC) while eliminating the use of a ventilator with tracheal intubation. It proves to be a highly desirable method for high-throughput studies on left ventricular overload, particularly in translational studies.
12:17
Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
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Cited by 4 •
2017
Full-root aortic valve replacement by stentless aortic xenograft is a viable option in patients with small aortic roots. We describe, a technique for the full-root implantation of stentless aortic xenografts, with emphasis on the management of the proximal suture line and coronary anastomoses, and discuss its limitations and alternative options.
FAQs
During ventricular systole, rising pressure in the left ventricle exceeds the pressure beyond the aortic valve, opening the valve and generating forward, pulsatile flow. When diastole begins, ventricular pressure falls and the valve closes, limiting reverse movement. This cycle links valve timing with the forward delivery and maintenance of systemic circulation.
The aortic valve regulates one-way passage between the left ventricle and ascending aorta, while the aortic wall contributes elastic support after blood enters the vessel. Valve closure limits backflow during diastole, and wall elasticity helps maintain circulation between ventricular contractions. Evaluating both structures can therefore clarify whether abnormal flow reflects valvular or aortic disease.
Changes in the expected forward or pulsatile pattern may be associated with impaired valve function, aortic dilation, aneurysms, dissection, or other abnormal blood-flow patterns. Flow assessment does not stand alone; clinicians interpret measurements alongside imaging of the valve and aorta. This combined view helps characterize cardiovascular disease and supports decisions about further evaluation or monitoring.
Echocardiography and Doppler ultrasound can assess flow-related features, while computed tomography and magnetic resonance imaging provide additional imaging approaches for evaluating the aorta and surrounding cardiovascular anatomy. The selected method depends on the clinical question and the structures requiring assessment. Using these tools, clinicians can investigate valve function, aortic enlargement, and suspected flow abnormalities.
Measurements help clinicians evaluate cardiovascular disease rather than simply document blood movement. Findings can contribute to diagnosis, risk assessment, treatment planning, and follow-up. In practice, the results are considered with evidence of valve dysfunction, aortic dilation, aneurysm, dissection, or abnormal flow, allowing clinicians to track changes and judge the significance of imaging findings.
Assessment becomes particularly relevant when clinicians are evaluating aortic valve function or structural abnormalities such as dilation, aneurysms, and dissection. It also helps characterize unusual flow patterns that may influence risk assessment and management. Repeated imaging can support monitoring over time, while the initial findings may inform treatment planning and the need for closer cardiovascular evaluation.