Hepatic Artery Cannulation
Hepatic Artery Cannulation - Related Videos
04:28
Cannulation of the Carotid Artery in a Rat Model
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2025
In this video, we demonstrate a surgical procedure to cannulate the left carotid artery in a rat model.
04:46
Targeting Liver Tumors with Oncolytic Viruses via the Hepatic Artery
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2025
The video demonstrates locoregional delivery of oncolytic viruses through hepatic arterial injection as a therapeutic approach for hepatocellular carcinoma. These viruses selectively replicate in tumor cells, inducing cell lysis and releasing tumor cell-associated antigens. This process triggers immunogenic cell death, inducing an anti-tumor response.
18:47
Surgical Procedures for a Rat Model of Partial Orthotopic Liver Transplantation with Hepatic Arterial Reconstruction
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Cited by 22 •
2013
Orthotopic liver transplantation in rats is an indispensable experimental model for biomedical research. Here we present our surgical procedures for orthotopic rat liver transplantation with hepatic arterial reconstruction using a 50% partial graft.
16:19
Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure
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Cited by 5 •
2014
Auxiliary liver transplantation provides a temporary support in acute hepatic failure, until regeneration of the failing liver. The heterotopic auxiliary liver transplantation (HALT) with portal vein arterialization (PVA) renders sufficient liver function. We developed an analogous technique in the rat, to examine the influence of the portal vein arterialization on the morphology and function of the graft.
07:56
A Comprehensive Rat Model For Assessing Hepatic Transport Pathways Through Simultaneous Lymphatic And Blood Vascular Sampling
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2026
This experimental protocol describes a hepatic lymph duct-cannulated rat model that enables direct and quantitative assessment of hepatic lymphatic and vascular drainage. The model allows simultaneous sampling of hepatic lymph and systemic blood to investigate hepatic transport, metabolism, and immune signaling, supporting studies of drug pharmacokinetics and liver-specific biology.
FAQs
Access to the hepatic artery provides a route focused on the liver’s arterial circulation. This positioning supports controlled regional administration and direct assessment of hepatic blood flow, drug distribution, or organ function. The approach is therefore valuable when investigators or clinicians need information or treatment directed specifically toward hepatic circulation rather than a general vascular target.
Once the catheter reaches the hepatic artery, its position provides targeted access for two complementary purposes. Clinicians can infuse an agent through the catheter under controlled conditions, or collect arterial blood associated with hepatic circulation. These capabilities support treatment delivery, monitoring, and research measurements involving hepatic exposure, perfusion, and function.
Catheter position determines whether the procedure can provide reliable access to the liver’s arterial network. Appropriate positioning supports delivery of agents to the intended hepatic circulation and permits collection of relevant arterial blood. It also helps preserve the targeted nature of the approach, which is important for liver-directed therapies and perfusion studies.
The technique can improve targeting by placing the delivery route within the arterial circulation serving the liver. This permits regional infusion rather than using access that is not specifically positioned for hepatic delivery. Such targeting is relevant to selected liver-directed therapies, interventional radiology procedures, and studies examining how an agent reaches or distributes within the liver.
The essential workflow begins by guiding a catheter through the vascular system toward the hepatic artery. After the catheter reaches the intended arterial location, clinicians can use it for controlled infusion, monitoring, or arterial blood collection. The resulting position provides the access required for treatment, perfusion assessment, or research measurements involving hepatic circulation.
Applications include regional drug delivery, hepatic perfusion studies, interventional radiology, selected liver-directed therapies, and investigations of hepatic organ function. The method is especially relevant when direct access to the liver’s arterial supply can support a controlled intervention or provide information about blood flow, drug distribution, or arterial blood associated with hepatic circulation.
This approach can support assessment of hepatic blood flow, drug distribution, and organ function while also enabling controlled administration of therapeutic or investigative agents. In medicine, those capabilities inform liver-directed treatment and monitoring. In research, they help investigators study how interventions interact with hepatic circulation and evaluate perfusion-related outcomes.