Topical Drug Application
Topical Drug Application - Related Videos
04:43
Topical Testing Assay: A Technique to Evaluate the Insecticidal Potential of Dopamine Receptor Antagonists on Adult Female Mosquitoes by Topical Application
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2025
In this video, we demonstrate the topical testing assay to determine the toxicity of a potential insecticide on adult female mosquitoes. Using a dopamine receptor antagonist that causes lethal inhibition of neurotransmission in mosquitoes, this method describes a way to evaluate the toxic effects of insecticides upon topical application.
09:03
Manufacture and Drug Delivery Applications of Silk Nanoparticles
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Cited by 49 •
2016
Nanoparticles are emerging as promising drug delivery systems for a broad range of indications. Here, we describe a simple yet powerful method to manufacture silk nanoparticles using reverse engineered Bombyx mori silk. These silk nanoparticles can be readily loaded with a therapeutic payload and subsequently explored for drug delivery applications.
13:29
Biodistribution of Nano-drug Carriers: Applications of SEM
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2023
Source: Peiman Shahbeigi-Roodposhti and Sina Shahbazmohamadi, Biomedical Engineering Department, University of Connecticut, Storrs, Connecticut Nanoparticles have been increasingly used research towards targeted drug delivery and controlled drug release. While most of these particles have been developed as polymeric or liposomal particles because of their biocompatibility, there is a trend in current research toward the use of metallic and magnetic nanoparticles. These metallic nanoparticles...
09:37
Topical Application Bioassay to Quantify Insecticide Toxicity for Mosquitoes and Fruit Flies
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Cited by 5 •
2022
We describe the methodology and importance of the topical application bioassay to measure insecticide susceptibility in mosquitoes and fruit flies. The presented assay is high-throughput, utilizes insect mass-thus allowing for calculating a mass-relativized lethal dose instead of concentration-and likely has lower variability than other similar methods.
13:17
The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport
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Cited by 48 •
2015
Here we describe a technique to cannulate the mesenteric lymph duct in rats which enables quantification of lipid and drug transport via the lymphatic system following intestinal delivery. The technique can be adapted to assess mesenteric lymph concentrations and/or transport of fluid, immune cells, peptides, proteins and lipophilic molecules.
FAQs
After application, the medication must be released from its formulation and move across the surface barrier. Its concentration and chemical properties influence how readily this transport occurs, while the treated tissue determines the barrier encountered. Pharmacology studies these relationships to understand why one formulation may produce stronger or more consistent delivery than another.
Tissue condition can affect how a medication crosses the surface barrier and where it distributes within the tissue. This is important because topical treatment depends on reaching the intended site at an effective level. Evaluating absorption and tissue distribution therefore helps connect the state of the body surface with therapeutic performance and safety.
A formulation can direct medication toward a specific body surface, allowing treatment of localized disorders such as inflammation, infection, or pain. When drug exposure remains concentrated near that site, systemic exposure may be limited compared with delivery intended to affect the whole body. This balance supports pharmacologic efficacy while helping guide safety evaluation.
The vehicle, such as a cream, ointment, gel, lotion, patch, or solution, serves as the formulation that carries the medication to the body surface. Drug release from that vehicle is a key part of delivery. Comparing formulation performance helps determine how effectively the medication becomes available for transport into the relevant tissue.
Planning begins with the intended body surface and the desired effect, whether local treatment or a possible systemic response. The selected formulation must release the medication and support transport across the tissue barrier. Pharmacologic assessment also considers concentration, chemical properties, tissue condition, absorption, and distribution so the approach can be matched to the treatment goal.
This approach is particularly relevant for localized skin, eye, and mucous-membrane disorders, including inflammation, infection, and pain. Research examines how much medication is absorbed, where it distributes, and how formulation performance affects results. These measurements help optimize efficacy, safety, and patient adherence while clarifying whether delivery remains local or may become systemic.