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A Modified Heterotopic Swine Hind Limb Transplant Model for Translational Vascularized Composite Allotransplantation (VCA) Research

Article DOI: 10.3791/50475-v • 09:09 min • October 14th, 2013
October 14th, 2013 •
1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1
1Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine

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Vascularized Composite Allotransplantations (VCA) have become a clinical reality. However, broad clinical application of VCA is limited by chronic multi-drug immunosuppression. The authors present a reliable and reproducible large animal model to translate novel immunomodulatory strategies that can minimize or potentially eliminate the need of immunosuppression in VCA.

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Modified Heterotopic Swine Hind Limb Transplant Model Translational Vascularized Composite Allotransplantation (VCA) Research Hand Transplant Face Transplant Musculoskeletal Trauma Tissue Loss Immunogenic Skin Component Chronic Multi-drug Immunosuppression Translational Studies Immunologic Features Of VCA Immunomodulatory Strategies Osteomyocutaneous Flap MHC-defined Swine Heterotopic Hind Limb Allotransplantation Near Infrared Laser Angiography Femoral Vascular Pedicle VCA Vascularized Bone Marrow Transplant
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