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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Article DOI: 10.3791/50670-v • 12:37 min • September 7th, 2013
September 7th, 2013 •
1,2, 1,3, 1,2, 1,2,3,4
1The Markey Cancer Center, University of Kentucky College of Medicine, 2Graduate Center for Toxicology, University of Kentucky College of Medicine, 3Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, 4Department of Pediatrics, University of Kentucky College of Medicine

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Epidermal melanin is induced by topical application of forskolin in a murine model of the fair-skinned UV-sensitive human. Pharmacologic manipulation of cAMP levels in the skin and epidermal darkening strongly protect against UV-mediated inflammation (sunburn) as measured by the minimum erythematous dose (MED) assay.

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Epidermal Melanin Induction Sunburn Protection Humanized Mouse Model Melanocortin 1 Receptor Gs-coupled Signaling Protein Melanocytes Adenylyl Cyclase CAMP Production Melanin Production UV Injury Protection Stem Cell Factor (Scf) K14-Scf Transgenic Mice Eumelanin Pigment Deposition UV-sensitive Phenotype Mc1r Signaling Ability Topical Agents Forskolin Extract Natural Root Extract Application UV Sensitivity Measurement
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