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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Article DOI: 10.3791/50868-v • 11:02 min • October 30th, 2013
October 30th, 2013 •
1, 1, 2, 1, 1, 1, 3, 1
1Department of Internal Medicine, Division of Hematology and Oncology, University of California, Davis, 2Comparative Pathology Laboratory, UC Davis School of Veterinary Medicine, University of California, Davis, 3Merck Serono Research, Merck KGaA, Darmstadt, Germany

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An N-butyl-N-(4-hydroxybutyl)nitrosamine-induced bladder cancer model was developed in human mucin 1 (MUC1) transgenic mice for the purpose of testing MUC1-directed immunotherapy. After administering a MUC1-targeted peptide vaccine, a cytotoxic T lymphocyte response to MUC1 was confirmed by measuring serum cytokine levels and T-cell specific activity.

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Invasive Transitional Cell Bladder Carcinoma MUC1 Transgenic Mice Immunotherapy Development Preclinical Model Bladder Cancer Mucin 1 OH-BBN Carcinogen Serum Cytokine Profile MUC1-targeted Peptide Vaccine Placebo Multiplex Fluorometric Microbead Immunoanalyses Interferon Gamma Interleukin-4 ELISpot Analysis T-cell Immune Response Histopathological Evaluations Tumor Type And Grade
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