Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice

Mariana Angoa-P&#233;rez; Michael J. Kane; Denise I. Briggs; Dina M. Francescutti; Donald M. Kuhn

doi:10.3791/50978

Journal

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Comportamiento

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Enterrar Mármol y Nestlet Trituración como pruebas de Conductas repetitivas, compulsivo-como en ratones

Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice

JoVE Revista
Comportamiento

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JoVE Revista Comportamiento

Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice

Enterrar Mármol y Nestlet Trituración como pruebas de Conductas repetitivas, compulsivo-como en ratones

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28,414 Views

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06:50 min

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December 24, 2013

DOI:

10.3791/50978-v

DOI:

10.3791/50978-v

•

06:50 min

December 24, 2013

•

28334 Views

Mariana Angoa-Pérez¹, Michael J. Kane¹, Denise I. Briggs¹, Dina M. Francescutti¹, Donald M. Kuhn¹

¹Research and Development Service, John D. Dingell VA Medical Center and Department of Psychiatry & Behavioral Neurosciences,Wayne State University School of Medicine

Summary

Disease, head injury, genetic modifications, and treatment of mice with drugs can have profound effects on behavior. Utilizing well-characterized and validated approaches such as marble burying and nestlet shredding, compulsive-like behaviors can be documented accurately in mice as models of human obsessive-compulsive disorder and autism spectrum disorder.