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Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
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Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice

Article DOI: 10.3791/52598-v • 06:39 min • April 13th, 2015
April 13th, 2015 •
*1,2, *1, 1, 1, 1, 1
1Cardiac Muscle Research Laboratory, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, 2Division of Cardiovascular Medicine, Chi-Mei Medical Center, Tainan
* These authors contributed equally

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Coronary flow reserve (CFR) is useful for assessment of myocardial oxygen demand and evaluation of cardiovascular risk. This study establishes a step-by-step transthoracic Doppler echocardiographic (TTDE) method for longitudinal monitoring of the changes in CFR, as measured from coronary artery in mice, under the experimental pressure overload of aortic banding.

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Ultrasound Coronary Artery Flow Coronary Flow Reserve Pressure Overload Model Mice Transthoracic Doppler Echocardiography CFR Intramyocardial Fibrosis Pericoronary Fibrosis Systolic To Diastolic Peak Velocity Aortic Banding Model Doppler Transthoracic Imaging Technique Septal Coronary Artery Hyperemia Isoflurane Resting Flow CFR Ratio S/D Ratio LV Dysfunction LV Mass Fractional Shortening
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