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Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Article DOI: 10.3791/54977-v • 09:40 min • January 19th, 2017
January 19th, 2017 •
1, 1, 2, 3, 4, 5, 1
1Davis Heart and Lung Research Institute, The Ohio State University, 2Laboratory of Clinical Investigation, National Institute on Aging, 3Division of Endocrinology, Diabetes and Metabolism, The Ohio State University, 4Department of Human Sciences, Human Nutrition, The Ohio State University, 5Division of Endocrinology and Diabetes, Department of Pediatrics, University of Pennsylvania

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This work demonstrates the feasibility of an in vivo phosphorus-31 magnetic resonance spectroscopy (31PMRS) technique to quantify mitochondrial oxidative phosphorylation (OXPHOS) capacity in human skeletal muscle.

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Phosphorus-31 Magnetic Resonance Spectroscopy In Vivo Measurement Mitochondrial Oxidative Phosphorylation Capacity Human Skeletal Muscle Noninvasive Technique Targeted Therapies Advantages Serial Investigation Functional Capabilities Equipment Set Up Subject Positioning Written Consent MRI Safety Siemens Avanto 1.5 Tesla System Phosphorous 31 Coil
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