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Biochemistry

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Generating Self-Assembling Human Heart Organoids Derived from Pluripotent Stem Cells

Article DOI: 10.3791/63097-v • 08:56 min • September 15th, 2021
September 15th, 2021 •
1,2, 1,2, 1,2, 1,2, 1,2
1Institute for Quantitative Health Science and Engineering, Division of Developmental and Stem Cell Biology, Michigan State University, 2Department of Biomedical Engineering, College of Engineering, Michigan State University

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Here, we describe a protocol to create developmentally relevant human heart organoids (hHOs) efficiently using human pluripotent stem cells by self-organization. The protocol relies on the sequential activation of developmental cues and produces highly complex, functionally relevant human heart tissues.

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Self-assembling Human Heart Organoids Pluripotent Stem Cells 3D Structure Developing Human Heart Cost-effective Reproducible Differentiation Steps Cell Types Chambers Vascular Network Modeling Cardiovascular Diseases Pharmacological Treatments High Throughput Congenital Heart Defects Cell Culture Skills Embryoid Bodies Detachment PSC Medium Single Cell Suspension
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