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Induction of Myocardial Infarction and Myocardial Ischemia-Reperfusion Injury in Mice

Article DOI: 10.3791/63257-v • 08:28 min • January 19th, 2022
January 19th, 2022 •
*1, *1, *1, 1, 1, 1, 1, 1, 1, 1
1Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
* These authors contributed equally

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Here we describe a simple and reproducible method that can induce myocardial infarction or myocardial ischemia-reperfusion injury in mice by precision ligation of the left anterior descending coronary artery through micromanipulation.

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Myocardial Infarction Myocardial Ischemia-reperfusion Injury Mice Cardiovascular Disease Mortality Heart Reflow Secondary Myocardial Injury Model Of Myocardial Infarction MI Model Precision Ligation Left Anterior Descending Coronary Artery (LAD) Micromanipulation Ligature Positioning ST-segment Changes Cardiac Troponin T (cTnT) Myocardial Systolic Function Evans-Blue/triphenyl Tetrazolium Chloride Staining Infarct Size Procedure Duration Controllable Infarct Size Mouse Survival
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