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Cancer Research

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JoVE Journal Cancer Research
Non-Invasive Ultrasound Assessment of Endometrial Cancer Progression in Pax8-Directed Deletion of the Tumor Suppressors Arid1a and Pten in Mice
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Non-Invasive Ultrasound Assessment of Endometrial Cancer Progression in Pax8-Directed Deletion of the Tumor Suppressors Arid1a and Pten in Mice

Article DOI: 10.3791/64732-v • 07:44 min • February 17th, 2023
February 17th, 2023 •
1, 2, 1,3, 4, 1,5,6, 1, 7, 4,8, 2,4,8, 1,4,8
1Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, 2Department of Obstetrics and Gynecology, Johns Hopkins University School of Medicine, 3Texas Tech University School of Veterinary Medicine, 4Department of Pathology, Johns Hopkins University School of Medicine, 5Department of Surgery, Johns Hopkins University School of Medicine, 6Department of Coloproctological Surgery, Juntendo University School of Medicine, 7Department of Human Pathology, Juntendo University School of Medicine, 8Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University

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This protocol describes a method for monitoring the progression of morphological changes over time in the uterus in an inducible mouse model of endometrial cancer using ultrasound imaging with correlation to gross and histological changes.

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Ultrasound Assessment Endometrial Cancer Progression Pax8-directed Deletion Tumor Suppressors Arid1a Pten Mice Non-invasive Manual Guided Ultrasound Uterine Pathology Longitudinal Studies Individual Variation Fewer Animals Pathologic Changes Mirroring Models Neoplasia Chronic Disease Urinary Tract Digestive Tract
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