Marianna A Tryfonidou Department of Clinical Sciences, Faculty of Veterinary Medicine Utrecht University Biography Publications Institution JoVE Articles Marianna A Tryfonidou has not added a biography. If you are Marianna A Tryfonidou and would like to personalize this page please email our Author Liaison for assistance. Publications Automatic Grading of Intervertebral Disc Degeneration in Lumbar Dog Spines JOR Spine. Jun, 2024 | Pubmed ID: 38633660 and Models Define a Molecular Signature Reference for Human Embryonic Notochordal Cells IScience. Feb, 2024 | Pubmed ID: 38357665 Targeted Screening of Inflammatory Mediators in Spontaneous Degenerative Disc Disease in Dogs Reveals an Upregulation of the Tumor Necrosis Superfamily JOR Spine. Mar, 2024 | Pubmed ID: 38222814 Epidemiology of Modic Changes in Dogs: Prevalence, Possible Risk Factors, and Association with Spinal Phenotypes JOR Spine. Sep, 2023 | Pubmed ID: 37780831 Recommendations for Intervertebral Disc Notochordal Cell Investigation: From Isolation to Characterization JOR Spine. Sep, 2023 | Pubmed ID: 37780826 An Insight on the -glycome of Notochordal Cell-rich Porcine Nucleus Pulposus During Maturation FASEB BioAdvances. Aug, 2023 | Pubmed ID: 37554546 Semi-synthetic Degradable Notochordal Cell-derived Matrix Hydrogel for Use in Degenerated Intervertebral Discs: Initial in Vitro Characterization Journal of Biomedical Materials Research. Part A. Dec, 2023 | Pubmed ID: 37539663 A Combined Western and Bead-Based Multiplex Platform to Characterize Extracellular Vesicles Tissue Engineering. Part C, Methods. Nov, 2023 | Pubmed ID: 37470213 Biomechanical Evaluation of a Novel Biomimetic Artificial Intervertebral Disc in Canine Cervical Cadaveric Spines JOR Spine. Jun, 2023 | Pubmed ID: 37361332 Acetabular Rim Extension Using a Personalized Titanium Implant for Treatment of Hip Dysplasia in Dogs: Short-term Results Frontiers in Veterinary Science. 2023 | Pubmed ID: 37152693 Mechanical Characterization of a Novel Biomimetic Artificial Disc for the Cervical Spine Journal of the Mechanical Behavior of Biomedical Materials. Jun, 2023 | Pubmed ID: 37087956 Dynamic Loading Leads to Increased Metabolic Activity and Spatial Redistribution of Viable Cell Density in Nucleus Pulposus Tissue JOR Spine. Mar, 2023 | Pubmed ID: 36994465 Harmonization and Standardization of Nucleus Pulposus Cell Extraction and Culture Methods JOR Spine. Mar, 2023 | Pubmed ID: 36994456 Lack of Concentration-dependent Local Toxicity of Highly Concentrated (5%) Versus Conventional 0.5% Bupivacaine Following Musculoskeletal Surgery in a Rat Model Journal of Experimental Orthopaedics. Mar, 2023 | Pubmed ID: 36884187 Sustained Release of Locally Delivered Celecoxib Provides Pain Relief for Osteoarthritis: a Proof of Concept in Dog Patients Osteoarthritis and Cartilage. Mar, 2023 | Pubmed ID: 36473675 Hyperosmolar Expansion Medium Improves Nucleus Pulposus Cell Phenotype JOR Spine. Sep, 2022 | Pubmed ID: 36203869 Intradiscal Injection of Human Recombinant BMP-4 Does Not Reverse Intervertebral Disc Degeneration Induced by Nuclectomy in Sheep Journal of Orthopaedic Translation. Nov, 2022 | Pubmed ID: 36196149 Detergent-Free Decellularization of Notochordal Cell-Derived Matrix Yields a Regenerative, Injectable, and Swellable Biomaterial ACS Biomaterials Science & Engineering. Sep, 2022 | Pubmed ID: 35942885 Roles and Responsibilities in Stem Cell Research: a Focus Group Study with Stem Cell Researchers and Patients Regenerative Medicine. Jul, 2022 | Pubmed ID: 35582744 Intervertebral Disc Degeneration in Warmblood Horses: Histological and Biochemical Characterization Veterinary Pathology. Mar, 2022 | Pubmed ID: 35291907 Folate Receptor Expression by Human Monocyte-Derived Macrophage Subtypes and Effects of Corticosteroids Cartilage. 2022 | Pubmed ID: 35255727 Injectable Hydrogels for Articular Cartilage and Nucleus Pulposus Repair: Status Quo and Prospects Tissue Engineering. Part A. Jun, 2022 | Pubmed ID: 35232245 Patient-specific 3D-printed Shelf Implant for the Treatment of Hip Dysplasia Tested in an Experimental Animal Pilot in Canines Scientific Reports. Feb, 2022 | Pubmed ID: 35194117 A Bovine Nucleus Pulposus Explant Culture Model Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Sep, 2022 | Pubmed ID: 34812520 The Function of CD146 in Human Annulus Fibrosus Cells and Mechanism of the Regulation by TGF-β Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Jul, 2022 | Pubmed ID: 34662464 Notochordal Cell-Based Treatment Strategies and Their Potential in Intervertebral Disc Regeneration Frontiers in Cell and Developmental Biology. 2021 | Pubmed ID: 35359916 Cell Sources Proposed for Nucleus Pulposus Regeneration JOR Spine. Dec, 2021 | Pubmed ID: 35005441 Comparing Hip Dysplasia in Dogs and Humans: A Review Frontiers in Veterinary Science. 2021 | Pubmed ID: 34977223 Sustained Intra-Articular Release and Biocompatibility of Tacrolimus (FK506) Loaded Monospheres Composed of [PDLA-PEG]--[PLLA] Multi-Block Copolymers in Healthy Horse Joints Pharmaceutics. Sep, 2021 | Pubmed ID: 34575514 The Genomic Profiling and MAMLD1 Expression in Human and Canines with Cushing's Disease BMC Endocrine Disorders. Sep, 2021 | Pubmed ID: 34517852 Prospective Evaluation of Local Sustained Release of Celecoxib in Dogs with Low Back Pain Pharmaceutics. Jul, 2021 | Pubmed ID: 34452138 Selection of Highly Proliferative and Multipotent Meniscus Progenitors Through Differential Adhesion to Fibronectin: A Novel Approach in Meniscus Tissue Engineering International Journal of Molecular Sciences. Aug, 2021 | Pubmed ID: 34445320 A Perspective on the Initiative to Develop a Multi-species Histopathology Series JOR Spine. Jun, 2021 | Pubmed ID: 34337339 A Comprehensive Tool Box for Large Animal Studies of Intervertebral Disc Degeneration JOR Spine. Jun, 2021 | Pubmed ID: 34337336 Recognizing the Ethical Implications of Stem Cell Research: A Call for Broadening the Scope Stem Cell Reports. Jul, 2021 | Pubmed ID: 34214488 Enhanced Extracellular Matrix Breakdown Characterizes the Early Distraction Phase of Canine Knee Joint Distraction Cartilage. Dec, 2021 | Pubmed ID: 34014119 Biomechanical Effects of a Titanium Intervertebral Cage As a Stand-alone Device, and in Combination with Locking Plates in the Canine Caudal Cervical Spine Veterinary Surgery : VS. Jul, 2021 | Pubmed ID: 33955033 Transformed Canine and Murine Mesenchymal Stem Cells As a Model for Sarcoma with Complex Genomics Cancers. Mar, 2021 | Pubmed ID: 33807947 "Old Drugs, New Tricks" - Local Controlled Drug Release Systems for Treatment of Degenerative Joint Disease Advanced Drug Delivery Reviews. 2020 | Pubmed ID: 33122086 Characterization of Biomaterials Intended for Use in the Nucleus Pulposus of Degenerated Intervertebral Discs Acta Biomaterialia. Sep, 2020 | Pubmed ID: 32771592 Bone Morphogenetic Proteins for Nucleus Pulposus Regeneration International Journal of Molecular Sciences. Apr, 2020 | Pubmed ID: 32295299 Hedgehog Proteins and Parathyroid Hormone-related Protein Are Involved in Intervertebral Disc Maturation, Degeneration, and Calcification JOR Spine. Dec, 2019 | Pubmed ID: 31891120 Aquaporin Expression in the Human and Canine Intervertebral Disc During Maturation and Degeneration JOR Spine. Mar, 2019 | Pubmed ID: 31463463 Instrumented Cervical Fusion in Nine Dogs with Caudal Cervical Spondylomyelopathy Veterinary Surgery : VS. Oct, 2019 | Pubmed ID: 31441092 Local Controlled Release of Corticosteroids Extends Surgically Induced Joint Instability by Inhibiting Tissue Healing British Journal of Pharmacology. Oct, 2019 | Pubmed ID: 31378925 Dog As a Model for Osteoarthritis: The FGF4 Retrogene Insertion May Matter Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Dec, 2019 | Pubmed ID: 31373395 Sequential Treatment of a Large Pituitary Corticotroph Neoplasm and Associated Neurological Signs in a Dog Journal of the American Animal Hospital Association. 2019 | Pubmed ID: 30776261 Applicability of a Modified Rat Model of Acute Arthritis for Long-Term Testing of Drug Delivery Systems Pharmaceutics. Feb, 2019 | Pubmed ID: 30736430 Effect of Biomaterial Electrical Charge on Bone Morphogenetic Protein-2-Induced Bone Formation Tissue Engineering. Part A. Jul, 2019 | Pubmed ID: 30612538 The Osteoinductive Effect of Controlled Bone Morphogenic Protein 2 Release Is Location Dependent Tissue Engineering. Part A. Feb, 2019 | Pubmed ID: 30101676 Leaping the Hurdles in Developing Regenerative Treatments for the Intervertebral Disc from Preclinical to Clinical JOR Spine. Sep, 2018 | Pubmed ID: 31463447 Successful Fishing for Nucleus Pulposus Progenitor Cells of the Intervertebral Disc Across Species JOR Spine. Jun, 2018 | Pubmed ID: 31463445 Intradiscal Delivery of Celecoxib-loaded Microspheres Restores Intervertebral Disc Integrity in a Preclinical Canine Model Journal of Controlled Release : Official Journal of the Controlled Release Society. Sep, 2018 | Pubmed ID: 30110616 Notochordal Cell Matrix: An Inhibitor of Neurite and Blood Vessel Growth? Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Dec, 2018 | Pubmed ID: 30035331 Hypoxia Negatively Affects Senescence in Osteoclasts and Delays Osteoclastogenesis Journal of Cellular Physiology. Jan, 2018 | Pubmed ID: 29932209 Biologic Canine and Human Intervertebral Disc Repair by Notochordal Cell-derived Matrix: from Bench Towards Bedside Oncotarget. May, 2018 | Pubmed ID: 29899873 IL4-10 Fusion Protein Has Chondroprotective, Anti-inflammatory and Potentially Analgesic Effects in the Treatment of Osteoarthritis Osteoarthritis and Cartilage. Aug, 2018 | Pubmed ID: 29775732 In Vitro and In Vivo Correlation of Bone Morphogenetic Protein-2 Release Profiles from Complex Delivery Vehicles Tissue Engineering. Part C, Methods. Jul, 2018 | Pubmed ID: 29756545 Bone Morphogenetic Protein-2 Release Profile Modulates Bone Formation in Phosphorylated Hydrogel Journal of Tissue Engineering and Regenerative Medicine. Jun, 2018 | Pubmed ID: 29603878 Comparing Hydrogels for Human Nucleus Pulposus Regeneration: Role of Osmolarity During Expansion Tissue Engineering. Part C, Methods. Apr, 2018 | Pubmed ID: 29457534 Focal Adhesion Signaling Affects Regeneration by Human Nucleus Pulposus Cells in Collagen- but Not Carbohydrate-based Hydrogels Acta Biomaterialia. Jan, 2018 | Pubmed ID: 29174589 Phosphate Functional Groups Improve Oligo[(Polyethylene Glycol) Fumarate] Osteoconduction and BMP-2 Osteoinductive Efficacy Tissue Engineering. Part A. May, 2018 | Pubmed ID: 29065776 Growth Plate Expression Profiling: Large and Small Breed Dogs Provide New Insights in Endochondral Bone Formation Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Jan, 2018 | Pubmed ID: 28681971 Intradiscal Application of a PCLA-PEG-PCLA Hydrogel Loaded with Celecoxib for the Treatment of Back Pain in Canines: What's in It for Humans? Journal of Tissue Engineering and Regenerative Medicine. Mar, 2018 | Pubmed ID: 28544701 Link-N: The Missing Link Towards Intervertebral Disc Repair is Species-specific PloS One. 2017 | Pubmed ID: 29117254 The Myth of Fibroid Degeneration in the Canine Intervertebral Disc: A Histopathological Comparison of Intervertebral Disc Degeneration in Chondrodystrophic and Nonchondrodystrophic Dogs Veterinary Pathology. Nov, 2017 | Pubmed ID: 28847244 Bone Morphogenetic Protein-2, But Not Mesenchymal Stromal Cells, Exert Regenerative Effects on Canine and Human Nucleus Pulposus Cells Tissue Engineering. Part A. Mar, 2017 | Pubmed ID: 27829314 Lack of Ubiquitin Specific Protease 8 (USP8) Mutations in Canine Corticotroph Pituitary Adenomas PloS One. 2016 | Pubmed ID: 28005997 Soluble and Pelletable Factors in Porcine, Canine and Human Notochordal Cell-conditioned Medium: Implications for IVD Regeneration European Cells & Materials. Aug, 2016 | Pubmed ID: 27572543 Increased Caveolin-1 in Intervertebral Disc Degeneration Facilitates Repair Arthritis Research & Therapy. Mar, 2016 | Pubmed ID: 26939667 Inflammatory Profiles in Canine Intervertebral Disc Degeneration BMC Veterinary Research. Jan, 2016 | Pubmed ID: 26757881 Characterization and Comparison of Canine Multipotent Stromal Cells Derived from Liver and Bone Marrow Stem Cells and Development. Jan, 2016 | Pubmed ID: 26462417 The Stimulatory Effect of Notochordal Cell-Conditioned Medium in a Nucleus Pulposus Explant Culture Tissue Engineering. Part A. Jan, 2016 | Pubmed ID: 26421447 Pedicle Screw-rod Fixation: a Feasible Treatment for Dogs with Severe Degenerative Lumbosacral Stenosis BMC Veterinary Research. Dec, 2015 | Pubmed ID: 26642756 The Species-specific Regenerative Effects of Notochordal Cell-conditioned Medium on Chondrocyte-like Cells Derived from Degenerated Human Intervertebral Discs European Cells & Materials. Sep, 2015 | Pubmed ID: 26388616 Biocompatibility and Intradiscal Application of a Thermoreversible Celecoxib-loaded Poly-N-isopropylacrylamide MgFe-layered Double Hydroxide Hydrogel in a Canine Model Arthritis Research & Therapy. Aug, 2015 | Pubmed ID: 26290179 Intradiscal Application of RhBMP-7 Does Not Induce Regeneration in a Canine Model of Spontaneous Intervertebral Disc Degeneration Arthritis Research & Therapy. May, 2015 | Pubmed ID: 26013758 Expression and Clinical Relevance of Paired Box Protein 7 and Sex Determining Region Y-box 2 in Canine Corticotroph Pituitary Adenomas Veterinary Journal (London, England : 1997). Jun, 2015 | Pubmed ID: 25956343 Increased Bone Morphogenetic Protein 7 Signalling in the Kidneys of Dogs Affected with a Congenital Portosystemic Shunt Veterinary Journal (London, England : 1997). May, 2015 | Pubmed ID: 25920772 Effect of Coculturing Canine Notochordal, Nucleus Pulposus and Mesenchymal Stromal Cells for Intervertebral Disc Regeneration Arthritis Research & Therapy. Mar, 2015 | Pubmed ID: 25890127 The Effects of Naproxen on Chondrogenesis of Human Mesenchymal Stem Cells Tissue Engineering. Part A. Jul, 2015 | Pubmed ID: 25873236 Conditioned Medium Derived from Notochordal Cell-rich Nucleus Pulposus Tissue Stimulates Matrix Production by Canine Nucleus Pulposus Cells and Bone Marrow-derived Stromal Cells Tissue Engineering. Part A. Mar, 2015 | Pubmed ID: 25370929 The Paracrine Feedback Loop Between Vitamin D₃ (1,25(OH)₂D₃) and PTHrP in Prehypertrophic Chondrocytes Journal of Cellular Physiology. Dec, 2014 | Pubmed ID: 24777663 Genome Wide Analysis Indicates Genes for Basement Membrane and Cartilage Matrix Proteins As Candidates for Hip Dysplasia in Labrador Retrievers PloS One. 2014 | Pubmed ID: 24498183 Potential Regenerative Treatment Strategies for Intervertebral Disc Degeneration in Dogs BMC Veterinary Research. Jan, 2014 | Pubmed ID: 24387033 Increased Osmolarity and Cell Clustering Preserve Canine Notochordal Cell Phenotype in Culture Tissue Engineering. Part C, Methods. Aug, 2014 | Pubmed ID: 24304309 Stem Cells in the Canine Pituitary Gland and in Pituitary Adenomas The Veterinary Quarterly. Dec, 2013 | Pubmed ID: 24320563 Gene Expression Profiling of Early Intervertebral Disc Degeneration Reveals a Down-regulation of Canonical Wnt Signaling and Caveolin-1 Expression: Implications for Development of Regenerative Strategies Arthritis Research & Therapy. Jan, 2013 | Pubmed ID: 23360510 Intervertebral Disc Degeneration in the Dog. Part 1: Anatomy and Physiology of the Intervertebral Disc and Characteristics of Intervertebral Disc Degeneration Veterinary Journal (London, England : 1997). Mar, 2013 | Pubmed ID: 23177522 Intervertebral Disc Degeneration in the Dog. Part 2: Chondrodystrophic and Non-chondrodystrophic Breeds Veterinary Journal (London, England : 1997). Mar, 2013 | Pubmed ID: 23154070 Canonical Wnt Signaling in the Notochordal Cell is Upregulated in Early Intervertebral Disk Degeneration Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Jun, 2012 | Pubmed ID: 22083942 Intraspecies Disparity in Growth Rate is Associated with Differences in Expression of Local Growth Plate Regulators American Journal of Physiology. Endocrinology and Metabolism. Dec, 2010 | Pubmed ID: 20858751 Increased Vitamin D-driven Signalling and Expression of the Vitamin D Receptor, MSX2, and RANKL in Tooth Resorption in Cats European Journal of Oral Sciences. Feb, 2010 | Pubmed ID: 20156263 Inflammatory Cytokines and the Nuclear Vitamin D Receptor Are Implicated in the Pathophysiology of Dental Resorptive Lesions in Cats Veterinary Immunology and Immunopathology. Dec, 2009 | Pubmed ID: 19556012 Author Spotlight: A Novel 3D-Printed Titanium Implant for Minimally Invasive Treatment of Hip Dysplasia in Young Dogs Irin Kwananocha1,2, Femke Verseijden1, Seyed A Kamali1, Joëll Magré3, Koen Willemsen3, Jacobine CM Schouten4, Daniela Salvatori4, Marianna A Tryfonidou1, Björn P Meij1 1Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, 2Research and Academic Service, Faculty of Veterinary Medicine, Kasetsart University, 3Department of Orthopedics, University Medical Center Utrecht, 4Department of Clinical Sciences, Anatomy and Physiology, Faculty of Veterinary Medicine, Utrecht University JoVE 66005 Biologie
Author Spotlight: A Novel 3D-Printed Titanium Implant for Minimally Invasive Treatment of Hip Dysplasia in Young Dogs Irin Kwananocha1,2, Femke Verseijden1, Seyed A Kamali1, Joëll Magré3, Koen Willemsen3, Jacobine CM Schouten4, Daniela Salvatori4, Marianna A Tryfonidou1, Björn P Meij1 1Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, 2Research and Academic Service, Faculty of Veterinary Medicine, Kasetsart University, 3Department of Orthopedics, University Medical Center Utrecht, 4Department of Clinical Sciences, Anatomy and Physiology, Faculty of Veterinary Medicine, Utrecht University JoVE 66005 Biologie