Cardiac Biomechanics
Cardiac Biomechanics - Related Videos
04:42
In Vivo Biomechanical Testing of Nerve: A Procedure for Biomechanical Analysis of Brachial Plexus Nerve Injury in a Neonatal Pig Model
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2025
In this video, we demonstrate the biomechanical testing of the brachial plexus nerve in a pig model to measure the threshold tensile strength of the nerve when subjected to stretching. This technique helps in determining the structural and mechanical properties of the nerve.
11:37
Cardiac Magnetic Resonance Imaging
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2023
Source: Frederick W. Damen and Craig J. Goergen, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana In this video, high field, small-bore magnetic resonance imaging (MRI) with physiological monitoring is demonstrated to acquire gated cine loops of the murine cardiovascular system. This procedure provides a basis for assessing left-ventricular function, visualizing vascular networks, and quantifying motion of organs due to respiration. Comparable small animal...
15:12
Preparation of Rat Tail Tendons for Biomechanical and Mechanobiological Studies
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Cited by 21 •
2010
This article describes the experimental procedures used to prepare rat tail tendons for biomechanical and mechanobiological studies. Several features of the main steps in preparation are demonstrated, beginning with extraction, cross-sectional area measurement, rinsing and loading into the bioreactor chamber.
05:08
The Mammalian Ocular Lens in Focus: Development, Anatomy, Physiology, Transparency, Biomechanics, and Age-Related Challenges
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2026
The function of the ocular lens to focus light onto the retina depends on tissue transparency, biomechanics, and refractive index. This review highlights the three-dimensional architecture of the lens and discusses the complex mechanisms that maintain tissue homeostasis.
08:25
Visualization of Streptococcus pneumoniae within Cardiac Microlesions and Subsequent Cardiac Remodeling
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Cited by 11 •
2015
Streptococcus pneumoniae forms discrete non-purulent microscopic lesions in the heart. Outlined is the protocol for a murine model of cardiac microlesion formation. Instruction is provided on microlesion visualization using microscopy, discrimination between early and late microlesions, and methods to detect cardiac remodeling in hearts of convalescent animals.
FAQs
Contraction of the myocardium generates pressure and wall stress, but the resulting motion is not a one-way effect. Tissue deformation changes as the heart interacts with blood, and valve motion participates in the same fluid-structure relationship. Examining these quantities together helps bioengineers relate muscular action to chamber mechanics and cardiovascular performance rather than interpreting pressure or motion in isolation.
Material properties govern how cardiac tissue deforms under mechanical forces. Combined with contraction and pressure, they influence observed motion and wall stress. Accounting for these properties helps computational models represent the heart as a mechanically responsive structure, which is important when interpreting deformation or investigating how altered cardiac mechanics may contribute to conditions such as heart failure or valve disease.
Strain quantifies tissue deformation, allowing researchers to describe how cardiac structures change during a heartbeat. Imaging can provide motion-related measurements, while computational models and laboratory measurements help analyze them alongside pressure, wall stress, and flow. This combination supports assessment of cardiac performance and provides a mechanical basis for investigating conditions such as heart failure.
A typical workflow combines imaging, computational modeling, and laboratory measurements. Imaging captures cardiac motion and structure, models examine interactions among tissue deformation, blood flow, pressure, and valve motion, and laboratory measurements provide additional mechanical information. Together, these sources support strain quantification and connect observed motion with the mechanical processes occurring during a heartbeat.
By combining measurements of motion and deformation with computational analysis, these studies can characterize cardiac performance for an individual case. The resulting mechanical information may help researchers and clinicians investigate heart failure or valve disease and support treatment planning tailored to a patient's cardiovascular condition. These analyses therefore connect measurable mechanics with decisions about diagnosis and intervention.
Mechanical analyses support the design and evaluation of cardiovascular implants and assistive devices by showing how they relate to tissue motion, pressure, blood flow, and valve behavior. In bioengineering, this provides a way to assess device performance within the interacting heart and cardiovascular system, rather than considering the device separately from the mechanics it must function within.