Nanoparticle Functionalization
Nanoparticle Functionalization - Related Videos
14:37
High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
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Cited by 7 •
2012
In this article, a high throughput method is presented for the synthesis of oligosaccharides and their attachment to the surface of polyanhydride nanoparticles for further use in targeting specific receptors on antigen presenting cells.
09:12
Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods
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Cited by 15 •
2018
We have engineered the capsid protein of hepatitis E virus as a theranostic nanoparticle (HEVNP). HEVNP self-assembles into a stable icosahedral cage in mucosal delivery. Here, we describe the modification of HEVNPs for tumor targeting by mutating surface-exposed residues to cysteines, which conjugate synthetic ligands that specifically bind tumor cells.
08:19
Synthesis, Characterization, and Functionalization of Hybrid Au/CdS and Au/ZnS Core/Shell Nanoparticles
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Cited by 3 •
2016
The synthesis of uniform gold nanoparticles coated with semiconductor shells of CdS or ZnS is performed. The semiconductor coating is conducted by first depositing a silver sulfide shell and exchanging the silver cations for zinc or cadmium cations.
08:09
A Technique to Functionalize and Self-assemble Macroscopic Nanoparticle-ligand Monolayer Films onto Template-free Substrates
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2014
A simple, robust and scalable technique to functionalize and self-assemble macroscopic nanoparticle-ligand monolayer films onto template-free substrates is described in this protocol.
02:53
Functionalized Nanoparticle Targeting of Ovarian Cancer: A Technique to Facilitate Folic Acid-conjugated Nanoparticle Contrast Agent Uptake by Ovarian Cancer Cells
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2023
In this video, we demonstrate a technique to facilitate the internalization of folic acid-capped copper sulfide nanoparticles (CuS NPs). Folic acid-functionalized CuS NPs have the ability to target folate-receptors which are overexpressed in many ovarian cancer cells.
FAQs
Surface-bound ligands, polymers, proteins, peptides, and other biomolecules provide an interface between the nanoparticle and its surroundings. Their identity and arrangement can influence molecular recognition, hydrophilicity, surface charge, and stability. In bioengineering, selecting an appropriate surface component helps tailor how particles disperse, interact with biological materials, and participate in cellular or molecular targeting.
Surface charge and hydrophilicity help determine how nanoparticles behave in surrounding materials and biological systems. Adjusting these properties can improve dispersion and alter interactions with cells or other biological components. Such control is valuable when researchers need particles to remain suitably distributed, support selective cellular uptake, or present a surface compatible with a particular biomedical application.
These strategies provide distinct ways to place functional molecules at a nanoparticle surface. Covalent bonds, adsorption, and affinity interactions can each connect ligands, polymers, proteins, peptides, or other biomolecules to the particle. The chosen interaction determines how the interface is established and helps researchers match surface modification with goals such as molecular recognition, delivery, sensing, or imaging.
Researchers can select surface components according to the property or biological interaction they want to control. A polymer or other coating may support dispersion and stability, while a protein, peptide, ligand, or related biomolecule may provide molecular recognition or influence cellular uptake. This goal-directed selection connects nanoparticle chemistry with the requirements of delivery, imaging, sensing, or tissue-related systems.
Functionalized nanoparticles can support drug or gene delivery by creating interfaces tailored to biological interactions and selective cellular uptake. Surface modification may also improve particle dispersion, helping maintain a more usable delivery system in surrounding materials. In bioengineering research, these features make functionalized particles adaptable platforms for transporting therapeutic cargo toward cells or biological environments of interest.
In biosensors, tailored surfaces can support detection by presenting components involved in molecular recognition. For biomedical imaging, functionalization can enhance nanoparticle contrast. In tissue engineering and regenerative medicine, modified particles can provide controllable platforms for presenting biological signals. These applications illustrate how surface design extends nanoparticles beyond passive materials toward systems that interact with specific biological processes.