Vascular Lock
Vascular Lock - Related Videos
01:16
Self-Locking Screw
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2023
A square-threaded screw jack is a mechanical device widely used for lifting heavy loads or applying considerable force. One of the key features that can make a screw jack more effective and reliable is its self-locking capability. A square-threaded screw jack carrying a load is considered self-locking if the screw retains its position even after the moment applied to it is removed. This occurs when the frictional force direction reverses, and the reaction force acts on the other side of the...
08:50
Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Cited by 25 •
2014
The degree of vascular dysfunction and contributing physiological mechanisms can be assessed in patients with chronic kidney disease by measuring brachial artery flow-mediated dilation, aortic pulse-wave velocity, and vascular endothelial cell protein expression.
14:18
Automation of Mode Locking in a Nonlinear Polarization Rotation Fiber Laser through Output Polarization Measurements
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Cited by 2 •
2016
A protocol to detect and automate mode locking in a pre-adjusted nonlinear polarization rotation fiber laser is presented. The detection of a sudden change in the output polarization state when mode locking occurs is used to command the alignment of an intra-cavity polarization controller in order to find mode-locking conditions.
08:24
Isolation of Murine Coronary Vascular Smooth Muscle Cells
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Cited by 11 •
2016
The purpose of this protocol is to demonstrate the isolation and culture techniques of murine primary vascular smooth muscle cells (VSMCs) from the coronary circulation. Once VSMCs have been isolated, they can be used for many standard culture techniques.
08:18
Engineered Vascularized Muscle Flap
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Cited by 6 •
2016
To date, thick tissue defects are typically reconstructed by applying autologous tissue flaps or engineered tissues. In this protocol, we present a new method for engineering vascularized tissue flap bearing an autologous pedicle, to serve as a substitute to autologous flaps.
FAQs
Its mechanical closure reduces or stops flow through a selected vessel, creating a defined period of vascular interruption. Researchers can then relate the change in perfusion to subsequent tissue responses rather than observing circulation changes without a controlled intervention. This makes the approach useful for examining how dependent a tumor or surrounding tissue is on a particular blood supply.
Clamping, clipping, or another occlusive mechanism provides a direct way to isolate or interrupt blood flow to a target region. That distinction matters because it helps separate effects linked to vascular access from broader changes in the tumor environment. The resulting model can support analysis of vascular function, tumor dependence on perfusion, and responses to altered circulation.
Perfusion and tissue response are the central outcomes identified for this approach. Researchers can compare how a tumor region or adjacent tissue changes when its blood supply is interrupted, using those observations to investigate vascular function and treatment response. In cancer studies, these measurements also help connect circulation changes with tumor growth and the behavior of the tumor microenvironment.
A typical workflow places the occlusive device on the vessel of interest, applies mechanical closure to restrict flow, and monitors perfusion and tissue response during the intervention. Because the restriction is temporary, the design can include restoration of flow after the observation period. The exact device and handling depend on the experimental vessel and the outcome being studied.
This approach is useful when investigators need to examine the consequences of isolating a tumor’s blood supply. It can support studies of tumor growth, drug delivery, vascular function, and treatment response. By changing circulation in a controlled setting, researchers can also evaluate how vascular interruption influences the tumor microenvironment and conditions associated with impaired blood flow.
Tumor angiogenesis concerns the vascular support associated with tumor development, and vascular interruption provides a way to test the functional importance of that support. Observing perfusion and tissue responses after occlusion can show how strongly the tumor depends on its blood supply. These findings may help assess strategies that target tumor-associated circulation or the broader microenvironment.