Dce-mri Quantification
Dce-mri Quantification - Related Videos
04:11
DCE-MRI of Orthotopic Pancreatic Tumor Xenografts: A Method to Assess Microvasculature in a Target Tumor Tissue
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2023
This video describes the technique of DCE-MRI for orthotropic pancreatic tumor xenografts in mice. DCE-MRI is a non-invasive method to analyze microvasculature in a target tissue, and useful to assess vascular response in a tumor following a novel therapy. This method will assist investigators to apply DCE-MRI for orthotopic gastrointestinal cancer mouse models.
10:26
A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
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Cited by 5 •
2015
The goal of this study is to use magnetic resonance venography with long-circulating gadolinium-based contrast agent and direct thrombus imaging for quantitative evaluation of DVT volume in a multicenter, clinical trial setting. Inter- and intra-observer variability assessments were conducted, and reproducibility of the protocol was determined.
06:06
Optogenetic Functional MRI
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Cited by 15 •
2016
This protocol describes the steps and data analysis required to successfully perform optogenetic functional magnetic resonance imaging (ofMRI). ofMRI is a novel technique that combines high-field fMRI readout with optogenetic stimulation, allowing for cell type-specific mapping of functional neural circuits and their dynamics across the whole living brain.
08:57
Quantification of Optic Nerve Cross Sectional Area on MRI: A Novel Protocol using Fiji Software
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2021
We provided a detailed protocol for a standardized method of optic nerve assessment and quantification using MRI, utilizing a widely available imaging sequence, and open access software for image analysis. Following this standardized protocol would provide meaningful data for comparison between different patients and different studies.
16:20
Hyperpolarized Xenon for NMR and MRI Applications
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Cited by 28 •
2012
The production of hyperpolarized xenon by means of spin exchange optical pumping (SEOP) is described. This method yields a ~10000-fold enhancement of the nuclear spin polarization of Xe-129 and has applications in nuclear magnetic resonance spectroscopy and imaging. Examples of gas phase and solution state experiments are given.
FAQs
The analysis follows the contrast agent through a sequence of repeated images, measuring how signal intensity changes over time after intravenous administration. Those signal-time patterns are converted into contrast-agent concentration, which can then be analyzed mathematically. The resulting measurements provide information about tissue perfusion and vascular permeability that is not available from static anatomical images alone.
Pharmacokinetic models provide the framework for translating contrast-agent concentration over time into quantitative parameters such as Ktrans, kep, and extracellular volume fraction. Because these values depend on the analysis model, consistent modeling is essential for reliable interpretation. Standardized modeling also makes measurements easier to compare across examinations and supports clinically meaningful assessment of tissue physiology.
Conventional MRI primarily depicts anatomical structure, whereas DCE-MRI quantification adds physiological information derived from contrast-agent behavior over time. This distinction allows imaging to examine characteristics such as tissue perfusion and vascular permeability rather than appearance alone. In medicine, the additional information can help characterize tumors and evaluate vascular changes associated with angiogenesis.
The examination begins with intravenous administration of a contrast agent, followed by repeated magnetic resonance images acquired as the agent produces changing signal intensity in the tissue. The resulting time series is processed to estimate contrast-agent concentration and fit pharmacokinetic models. Consistent timing, injection conditions, and image acquisition are important because each affects the quantitative measurements.
Quantitative results depend on how the contrast agent is administered and how rapidly images capture its passage through tissue. Variations in injection or acquisition can alter the measured signal-time pattern before modeling begins. Standardized procedures therefore improve reliability and clinical interpretability, helping ensure that differences in parameters reflect tissue physiology rather than inconsistent examination conditions.
Its applications include characterizing tumors, assessing angiogenesis, evaluating tissue blood flow, and monitoring response to therapy. The measurements can reveal physiological changes that may not be evident from anatomy alone, making them useful for studying tumor vascular behavior and treatment-associated changes. Reliable application depends on standardized acquisition, contrast administration, and pharmacokinetic analysis.