Hepatic Artery Perfusion
Hepatic Artery Perfusion - Related Videos
09:52
Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
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Cited by 23 •
2015
Here, we present a protocol how to perform an isolated liver perfusion (IHP) with melphalan and we also discuss IHP as a treatment option for liver metastases of uveal melanoma.
09:02
Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
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Cited by 12 •
2016
In this manuscript, we describe percutaneous isolated hepatic perfusion with simultaneous chemofiltration as treatment for unresectable liver metastases. This procedure is performed under general anaesthesia in the angiosuite by an experienced team, consisting of an interventional radiologist, a clinical perfusionist and anaesthesiologist.
04:46
Targeting Liver Tumors with Oncolytic Viruses via the Hepatic Artery
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2025
The video demonstrates locoregional delivery of oncolytic viruses through hepatic arterial injection as a therapeutic approach for hepatocellular carcinoma. These viruses selectively replicate in tumor cells, inducing cell lysis and releasing tumor cell-associated antigens. This process triggers immunogenic cell death, inducing an anti-tumor response.
18:47
Surgical Procedures for a Rat Model of Partial Orthotopic Liver Transplantation with Hepatic Arterial Reconstruction
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Cited by 22 •
2013
Orthotopic liver transplantation in rats is an indispensable experimental model for biomedical research. Here we present our surgical procedures for orthotopic rat liver transplantation with hepatic arterial reconstruction using a 50% partial graft.
16:19
Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure
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Cited by 5 •
2014
Auxiliary liver transplantation provides a temporary support in acute hepatic failure, until regeneration of the failing liver. The heterotopic auxiliary liver transplantation (HALT) with portal vein arterialization (PVA) renders sufficient liver function. We developed an analogous technique in the rat, to examine the influence of the portal vein arterialization on the morphology and function of the graft.
FAQs
Arterial delivery supplies oxygen to hepatocytes and biliary structures, allowing the liver to remain metabolically active under controlled conditions. When preservation solution is used instead of blood, the same route supports organ preservation and evaluation without recreating every feature of circulating blood. This makes the approach useful for studying tissue condition, vascular behavior, and functional maintenance.
Controlled flow and pressure help recreate arterial circulation in a reproducible way. They also make it possible to observe how the organ responds through changes in vascular resistance, oxygen use, and biochemical function. Maintaining defined circulation conditions is therefore important when comparing liver responses, assessing preservation, or determining whether an organ remains functionally viable.
Vascular resistance provides information about how readily fluid passes through the liver’s arterial circulation under the selected conditions. Interpreted with flow and pressure, it helps characterize vascular behavior rather than relying only on whether perfusion is occurring. In transplantation research and preservation studies, these measurements contribute to broader assessments of graft condition and organ performance.
Oxygen use and biochemical function provide complementary evidence about tissue activity during perfusion. Oxygen-related measurements indicate whether the organ is using the supplied oxygen, while biochemical observations add information about functional performance. Together with vascular resistance, these indicators help researchers evaluate organ condition, compare preservation settings, and interpret responses to treatment in a controlled system.
A basic workflow delivers blood or preservation solution through the hepatic artery, establishes controlled flow and pressure, and monitors the organ’s response. Relevant observations include vascular resistance, oxygen use, and biochemical function. This sequence connects the perfusion conditions with measurable outcomes, allowing investigators to assess tissue support, preservation status, or treatment response without relying on a single indicator.
In transplantation research, the method is used to study ex vivo liver preservation and evaluate whether a graft remains viable outside the body. Controlled arterial circulation provides a setting for monitoring vascular and biochemical behavior during preservation. These observations can help researchers examine preservation options, assess graft condition, and investigate approaches intended to improve transplantation outcomes.
Perfusion creates an opportunity to observe liver function while preservation is taking place, rather than evaluating the organ only after storage or transplantation. Measurements of vascular resistance, oxygen use, and biochemical function supply evidence about the graft’s condition. Researchers can use these findings to compare preservation options and investigate whether a liver retains characteristics associated with viability.
The hepatic artery can provide a route for regional treatment delivery in liver disease research and clinical settings. Perfusion also allows investigators to monitor how the liver responds through oxygen use, vascular resistance, and biochemical function. This combination of targeted delivery and measurable response supports studies of treatment behavior while preserving attention to hepatic physiology and organ condition.