Balb/c Mice
Balb/c Mice - Related Videos
11:36
Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
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Cited by 6 •
2020
We describe an in vivo immunization, translational hepatitis model in BALB/c mice that can be utilized to study the pathogenesis of drug-induced autoimmune hepatitis including sex differences seen in this disease. We will describe how this model demonstrates reproducible analyses using in vivo and in vitro experimental techniques.
05:39
A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis
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Cited by 4 •
2021
Necrotizing enterocolitis (NEC) is the most severe gastrointestinal (GI) disease that often occurs in premature infants, especially very low birth weight infants, with high mortality and unclear pathogenesis. The cause of NEC may be related to inflammatory immune regulatory system abnormalities. An NEC animal model is an indispensable tool for NEC disease immune research. NEC animal models usually use C57BL/6J neonatal mice; BALB/c neonatal mice are rarely used. Related studies have shown that...
07:19
High Sensitivity 5-hydroxymethylcytosine Detection in Balb/C Brain Tissue
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Cited by 56 •
2011
The EpiMark 5-hmC and 5-mC Analysis Kit can be used to analyze and quantitate 5-methylcytosine and 5-hydroxymethylcytosine within a spe cific locus. The kit distinguishes 5-mC from 5-hmC by the addition of glucose to the hydroxyl group of 5-hmC via an enzymatic reaction utilizing β-glucosyltransferase (T4-BGT). When 5-hmC occurs In the context of CCGG, this modification converts a cleavable MspI site to a non-cleavable site.
07:54
A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice
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Cited by 9 •
2017
Bacteriocins are believed to play a key role in defining microbial diversity in different ecological niches. Here, we describe an efficient procedure to assess how bacteriocins affect gut microbiota composition in an animal model.
09:39
Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages
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2013
We set out to determine tolerable concentrations of three fatty acids (oleic, linoleic and linolenic acids) and cholera toxin that did not significantly and adversely affect cell survival by solubilizing the fatty acids and the toxin and using them in cell survival assays.
FAQs
Genetic uniformity reduces variation between animals, making it easier to associate observed differences with an infection, immune challenge, drug, or other intervention. This consistency strengthens comparisons among experimental groups and supports reproducible findings. In medicine, that clearer attribution helps researchers evaluate whether a treatment changes disease-related or immune outcomes rather than merely reflecting underlying genetic differences.
Controlled breeding preserves the closely related genetic background that gives BALB/c studies their consistency. By maintaining this background across generations, researchers can compare disease models, immune responses, and treatment effects under more similar biological conditions. The resulting experimental control supports studies in which the intervention, rather than uncontrolled genetic variation, is the main factor being evaluated.
The strain’s characteristic immune-response patterns and susceptibility to selected disease models influence which experimental questions it can address effectively. These features allow investigators to examine how infections, immune challenges, or treatments affect disease and inflammation in a defined biological setting. They also require researchers to interpret findings in relation to the strain’s particular response profile.
Researchers expose BALB/c mice to selected disease-related conditions or immune challenges and then examine the resulting responses. Because the animals share a controlled genetic background, changes associated with infection, inflammation, cancer, or another intervention can be studied more systematically. This approach helps connect experimental triggers with disease mechanisms and provides evidence for evaluating potential therapeutic strategies.
BALB/c mice support several areas of biomedical investigation, including infectious disease, inflammation, cancer, monoclonal antibody production, and vaccine research. Their value differs by study goal: researchers may examine disease development, immune effects, antibody-related work, or responses to vaccination. Together, these applications make the strain useful for studying both biological mechanisms and candidate medical interventions.
Treatment studies in BALB/c mice can provide evidence about therapeutic efficacy and responses to disease or immune challenges. Researchers use these results to determine whether an approach produces a meaningful effect in a controlled experimental model. Promising findings can then support decisions about advancing an intervention to further preclinical testing, while remaining specific to the model examined.