Necrotic Core
Necrotic Core - Related Videos
02:10
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Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins. The paradox Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their main responsibility is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. While on the other hand, they must allow polymerase enzymes to access DNA...
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This video demonstrates the development of necrotizing enterocolitis disease in a human-derived neonatal enteroid model induced by lipopolysaccharides treatment. This model helps to study intestinal pathophysiology.
02:23
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Source: Stauffer, S. et al., In Vitro Disassembly of Influenza A Virus Capsids by Gradient Centrifugation. J. Vis. Exp. (2016)This video demonstrates the effect of pH on the solubilization of influenza A viral cores. Gel electrophoresis and protein staining reveal the progressive disassembly of the core structure under acidic conditions.
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A Protocol for Collecting and Constructing Soil Core Lysimeters
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A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis
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Cited by 4 •
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Necrotizing enterocolitis (NEC) is the most severe gastrointestinal (GI) disease that often occurs in premature infants, especially very low birth weight infants, with high mortality and unclear pathogenesis. The cause of NEC may be related to inflammatory immune regulatory system abnormalities. An NEC animal model is an indispensable tool for NEC disease immune research. NEC animal models usually use C57BL/6J neonatal mice; BALB/c neonatal mice are rarely used. Related studies have shown that...
FAQs
Formation follows a mismatch between tissue demand and available blood flow. Oxygen and nutrient deprivation first creates severe cellular stress, then damages membranes and causes irreversible injury. As membrane integrity is lost, cellular debris accumulates within the affected region. This sequence explains why the core marks tissue with markedly reduced viability.
Inflammation may amplify injury at the margins of the damaged region. The necrotic center already contains irreversibly injured cells and accumulated debris, while inflammatory activity at its boundaries can extend local tissue damage. Assessing both the core and its margins therefore helps characterize the extent and severity of the underlying lesion.
The same broad pattern can arise in different medical settings when tissue demands exceed its blood supply. In solid tumors, ischemic injuries, and atherosclerotic plaques, a necrotic core provides evidence of severe local cellular stress. Its meaning must therefore be interpreted within the surrounding disease process rather than treated as a diagnosis by itself.
Histology gives pathologists tissue-level evidence of the lesion’s cellular condition. Examination can identify the damaged central region, the accumulation of cellular debris, and changes near its margins where inflammation may contribute to further injury. These findings help characterize disease and support assessment of tissue viability within the sampled material.
Medical imaging helps clinicians characterize disease and evaluate whether tissue remains viable without relying only on microscopic examination. Imaging findings can be considered alongside the suspected lesion or injury to identify the extent of the affected region and its clinical significance. This information contributes to evaluating progression and potential complications.
A necrotic core can provide information about tissue viability, disease severity, and possible progression. Clinicians and pathologists integrate its presence with histologic or imaging findings to evaluate complications and understand the lesion more fully. That assessment may help guide treatment decisions, particularly when determining how severely the tissue has been affected.