Spinal Surgery Model

A spinal surgery model is a controlled anatomical, biological, or computational representation used to study procedures that alter the spinal cord, vertebrae, or surrounding tissues. By reproducing surgical access, tissue manipulation, mechanical forces, or neural injury under defined conditions, these models help researchers examine motor and sensory pathways, tissue responses, and potential complications. In neuroscience, spinal surgery models support training, evaluation of surgical techniques and devices, and investigation of how spinal damage affects neural function and recovery. Findings can improve experimental reproducibility, guide neuroprotective strategies, and inform the development of treatments for spinal cord injury and other disorders requiring surgery.

Spinal Surgery Model - Related Videos

Research

JoVE EoE - Neuropathology

Performing Thoracic Spinal Cord Hemisection Surgery in Rats

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2025

This video demonstrates the surgical procedure for performing a thoracic spinal cord hemisection in rats. It outlines the steps to expose the T8 spinal cord segment, perform the hemisection to disrupt neural tracts on one side, and provide post-operative care.

Intraoperative Ultrasound in Spinal Surgery

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2022

Here, we present a protocol on the use of intraoperative ultrasound in spinal surgery, particularly in cases of intradural lesions and lesions in the ventral spinal canal when using a posterior approach.

Research

JoVE Journal - Medicine
Free Sample

Calibrated Forceps Model of Spinal Cord Compression Injury

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Cited by 57 •

2015

Spinal cord injury models should be highly reproducible. We demonstrate that the calibrated forceps compression model of spinal cord injury is an easy to use surgical method for generating reproducible injuries to the murine spinal cord.

Research

JoVE Journal - Medicine
Free Sample

A Neonatal Mouse Spinal Cord Compression Injury Model

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Cited by 4 •

2016

This article describes a method for generating a reproducible spinal cord compression injury (SCI) in the neonatal mouse. The model provides an advantageous platform for studying mechanisms of adaptive plasticity that underlie spontaneous functional recovery.

Reproducable Paraplegia by Thoracic Aortic Occlusion in a Murine Model of Spinal Cord Ischemia-reperfusion

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Cited by 8 •

2014

The lack of mechanistic understanding of spinal cord ischemia-reperfusion injury has hindered further adjuncts to prevent paraplegia following high risk aortic operations. Thus, the development of animal models is imperative. This manuscript demonstrates reproducible lower extremity paralysis following thoracic aortic occlusion in a murine model.

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