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Bioengineering

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JoVE Journal Bioengineering
Kimyasal epigenetik değiştiriciler ile hücresel makine yeniden yönlendirerek Gen transkripsiyonu bastırmak
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Kimyasal epigenetik değiştiriciler ile hücresel makine yeniden yönlendirerek Gen transkripsiyonu bastırmak

Article DOI: 10.3791/58222-v • 10:28 min • September 20th, 2018
September 20th, 2018 •
1, 2, 3, 3, 4
1Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, Curriculum in Genetics and Molecular Biology, University of North Carolina, 2College of Arts and Sciences, Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina, 3Chemical Biology and Drug Discovery, Pharmacological Sciences and Oncological Sciences, Icahn School of Medicine at Mount Sinai, 4Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, University of North Carolina

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Kromatin çevre düzenlenmesi uygun gen ekspresyonu için gerekli temel bir işlemdir. Burada, biz gen ekspresyonu kromatin değiştirme alımı yoluyla kontrol etmek için bir yöntem tarif gene özgü ve geri dönüşümlü bir şekilde makine.

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Biyomühendislik sayı: 139 Kimya Biyoloji bifonksiyonel molekülleri kimyasal indüklenen yakınlık kromatin yönetmelik gen baskı histon deacetylase epigenetik kimyasal epigenetik değiştiriciler CEMs
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