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Journal / Cancer Research / 生成毛因诱导多能干细胞衍生的肿瘤抗原特异性胸腺移民的三维胸腺培养系统…
JoVE Journal
Cancer Research

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JoVE Journal Cancer Research
生成毛因诱导多能干细胞衍生的肿瘤抗原特异性胸腺移民的三维胸腺培养系统
A Detailed Protocol for Characterizing the Murine C1498 Cell Line and its Associated Leukemia Mouse Model
Journal (Cancer Research)
A Detailed Protocol for Characterizing the Murine C1498 Cell Line and its Associated Leukemia Mouse Model
Co-Culture and Transduction of Murine Thymocytes on Delta-Like 4-Expressing Stromal Cells to Study Oncogenes in T-Cell Leukemia
Journal (Cancer Research)
Co-Culture and Transduction of Murine Thymocytes on Delta-Like 4-Expressing Stromal Cells to Study Oncogenes in T-Cell Leukemia
 
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生成毛因诱导多能干细胞衍生的肿瘤抗原特异性胸腺移民的三维胸腺培养系统

Article DOI: 10.3791/58672-v • 10:44 min • August 9th, 2019
August 9th, 2019 •
*1,2, *1,2, 1,2, 1,2, 1,2, 1,2, 1,2, 1, 3, 1,2
1Surgery Branch, National Cancer Institute, NIH, 2Center for Cell-Based Therapy, National Cancer Institute, NIH, 3Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, NIH
* These authors contributed equally

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本文介绍了一种通过三维(3D)胸腺培养系统生成肿瘤抗原特异性诱导多能干细胞衍生胸腺(iTE)的新方法。iTE 是 T 细胞的同质子集,与天真的 T 细胞密切相关,具有增殖、记忆形成和肿瘤抑制的能力。

Tags

癌症研究 问题 150 干细胞 诱导多能干细胞 免疫学 收养细胞转移 T细胞分化 肿瘤抗原特异性 3D培养 胎儿胸腺器官培养
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