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Journal / Neuroscience / TDP-43在斑马鱼幼虫脊髓运动神经元中的光遗传学相变…
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JoVE Journal Neuroscience
TDP-43在斑马鱼幼虫脊髓运动神经元中的光遗传学相变
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TDP-43在斑马鱼幼虫脊髓运动神经元中的光遗传学相变

Article DOI: 10.3791/62932-v • 07:14 min • February 25th, 2022
February 25th, 2022 •
1, 1, 2,3
1Department of Chemical Biology, Tokyo Medical University, 2Division of Molecular and Developmental Biology, National Institute of Genetics, 3Department of Genetics, Graduate University for Advanced Studies (SOKENDAI)

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我们描述了一种以斑马鱼为模型的模式，通过光在脊髓运动神经元中诱导TAR DNA结合蛋白43（TDP-43）的相变。

Tags

神经科学，第180期，神经退行性疾病，ALS，光滴系统，隐色素2，TDP-43，斑马鱼，脊髓运动神经元， mnr2b，BAC转基因
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