יישומים קליניים של תאי גזע אפידרמליים

Epidermal stem cells or EpiSCs are multipotent stem cells that divide and differentiate into new skin cells.

Native EpiSCs maintain skin homeostasis and repair skin injuries. However, these EpiSCs cannot naturally repair severe injuries such as those from third-degree burns, diabetic ulcers, and some vascular diseases.

For such critical wounds, doctors can culture EpiSCs along with the patient's intact skin tissue on specialized biomaterials to form cultured epidermal autografts or CEAs. The CEAs are placed on the wound, and the EpiSCs in the graft promote wound repair and closure.

As the EpiSCs originate from a patient's own body, the chances of immune rejection are reduced. They also prevent scar formation during healing.

Studies in animal models have demonstrated that EpiSCs can regenerate other epithelia, such as the cornea, the outermost layer of the eye. Therefore, ongoing research shows the potential of EpiSCs for treating other types of epithelial injuries.