Question 1

What causes insulin deficiency in diabetic ketoacidosis?

Accepted Answer

In type 1 diabetes, insulin deficiency is typically absolute due to pancreatic beta cell destruction. In type 2 diabetes, severe relative insulin deficiency develops during physiological stressors like infection. Both scenarios impair glucose uptake and trigger counterregulatory hormones, worsening hyperglycemia and initiating the cascade toward metabolic emergency.

Question 2

How does insulin deficiency lead to ketone body formation?

Accepted Answer

Without insulin, lipolysis proceeds unchecked, releasing free fatty acids from adipose tissue. The liver undergoes increased fatty acid beta-oxidation, generating acetyl-CoA that converts into ketone bodies—acetoacetate, beta-hydroxybutyrate, and acetone. Excess ketone accumulation causes high anion gap metabolic acidosis, a hallmark of DKA.

Question 3

What role does osmotic diuresis play in diabetic ketoacidosis?

Accepted Answer

Hyperglycemia exceeds the renal threshold, causing glucose excretion in urine. This osmotic diuresis depletes water, sodium, potassium, and phosphate, leading to polyuria and volume depletion. Continued fluid loss reduces renal perfusion, further impairing clearance of glucose and ketones, worsening the metabolic emergency.

Question 4

Why does serum potassium appear normal despite total-body depletion in DKA?

Accepted Answer

Acidosis and insulin deficiency drive potassium shifts from intracellular to extracellular compartments, masking severe total-body depletion. Serum levels may appear normal or elevated despite significant losses. When insulin therapy and acidosis correction begin, potassium rapidly re-enters cells, creating dangerous hypokalemia unless potassium is replaced.

Question 5

How do counterregulatory hormones contribute to hyperglycemia in DKA?

Accepted Answer

Insulin deficiency allows unopposed actions of glucagon, cortisol, catecholamines, and growth hormone. These counterregulatory hormones drive gluconeogenesis and glycogenolysis in the liver while blocking glucose uptake in insulin-dependent tissues. The result is marked hyperglycemia that exceeds the renal threshold for reabsorption.

Question 6

What causes altered mental status in diabetic ketoacidosis?

Accepted Answer

Rising plasma osmolality, often exceeding 330 mOsm/kg, causes cerebral dehydration leading to confusion, stupor, or coma. Hyperosmolality, rather than acidosis alone, is the primary cause of altered consciousness. Kussmaul respirations develop as the respiratory center responds to acidosis, lowering CO2 to compensate.

Question 7

What defines the metabolic triad of diabetic ketoacidosis?

Accepted Answer

Diabetic ketoacidosis is characterized by three interconnected metabolic derangements: hyperglycemia from impaired glucose uptake and increased hepatic production, metabolic acidosis from ketone body accumulation, and fluid and electrolyte loss from osmotic diuresis. Together, these disturbances define the pathophysiologic basis of this life-threatening emergency.

קטואצידוזיס סוכרתי II: פתופיזיולוגיה