Question 1

What causes chronic pancreatitis to develop?

Accepted Answer

Chronic pancreatitis results from repeated tissue injury and premature enzyme activation in the pancreas. Chronic alcohol use is the leading cause, accounting for 70–80% of cases. Other risk factors include smoking, hypertriglyceridemia, ductal obstruction, elevated calcium levels, and genetic mutations. Some cases are idiopathic when no identifiable cause exists.

Question 2

How does chronic pancreatitis differ from acute pancreatitis?

Accepted Answer

Chronic pancreatitis is progressive inflammation causing irreversible damage, fibrosis, and loss of pancreatic function. It may develop gradually after multiple episodes of acute pancreatitis or independently. Unlike acute pancreatitis, chronic pancreatitis results in permanent tissue destruction and long-standing dysfunction rather than temporary inflammation.

Question 3

What happens to pancreatic tissue during chronic pancreatitis?

Accepted Answer

Enzyme-mediated autodigestion and immune activation destroy pancreatic tissue, leading to fibrosis and eventual pancreatic atrophy. Progressive tissue damage impairs both exocrine and endocrine function. Loss of insulin-producing cells results in endocrine dysfunction, often causing diabetes, while declining enzyme secretion leads to exocrine insufficiency.

Question 4

What are the early symptoms of chronic pancreatitis?

Accepted Answer

Symptoms often begin as chronic or post-prandial pain in the upper abdomen, potentially radiating to the back. As tissue damage progresses, patients experience bloating, steatorrhea, malabsorption, and unintentional weight loss due to impaired exocrine function. These manifestations reflect declining enzyme secretion and nutrient absorption.

Question 5

How does alcohol use contribute to chronic pancreatitis?

Accepted Answer

Chronic alcohol use is the most common risk factor, accounting for 70–80% of chronic pancreatitis cases. Long-term heavy consumption damages acinar cells and promotes formation of protein plugs within pancreatic ducts. When combined with smoking, alcohol significantly increases disease risk and accelerates pancreatic damage.

Question 6

What complications can develop from chronic pancreatitis?

Accepted Answer

Advanced chronic pancreatitis may lead to ductal stones, pseudocysts, and increased risk of pancreatic cancer. Loss of exocrine function causes steatorrhea and malabsorption, while endocrine insufficiency results in insulin-dependent diabetes. These complications reflect progressive destruction of pancreatic parenchyma and functional decline.

Question 7

Which genetic mutations increase the risk of chronic pancreatitis?

Accepted Answer

Genetic mutations including PRSS1 (cationic trypsinogen), CFTR (cystic fibrosis transmembrane conductance regulator), and SPINK1 can disrupt enzyme regulation or ductal secretion, predisposing individuals to chronic pancreatitis. These mutations represent heritable risk factors that may cause disease independently or in combination with environmental triggers.

דלקת לבלב כרונית I: מבוא