Rolling Velocities
Rolling Velocities - Related Videos
04:24
Studying Cell Rolling Trajectories on Asymmetric Receptor Patterns
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Cited by 3 •
2011
We describe a protocol to observe and analyze cell rolling trajectories on asymmetric receptor-patterned substrates. The resulting data are useful for engineering of receptor-patterned substrates for label-free cell separation and analysis.
01:09
Rolling Without Slipping
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2023
People have observed the rolling motion without slipping ever since the invention of the wheel. For example, one can look at the interaction between a car's tires and the surface of the road. If the driver presses the accelerator to the floor so that the tires spin without the car moving forward, there must be kinetic friction between the wheels and the road's surface. If the driver slowly presses the accelerator, causing the car to move forward, the tires roll without slipping. It is essential...
01:14
Rolling With Slipping
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2025
Rolling with slipping is a physical phenomenon that occurs when a rolling object experiences both rotational and linear motion but also experiences frictional forces that cause slipping. This phenomenon can occur in various situations, such as when a tire rolls on a wet road or a ball rolls on a rough surface. An object's rolling motion is characterized by its rotation around its axis, while linear motion refers to the object's translational motion along a surface. Frictional forces can affect...
11:04
Systematic Analysis of In Vitro Cell Rolling Using a Multi-well Plate Microfluidic System
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Cited by 4 •
2013
This study used a multi-well plate microfluidic system, significantly increasing throughput of cell rolling studies under physiologically relevant shear flow. Given the importance of cell rolling in the multi-step cell homing cascade and the importance of cell homing following systemic delivery of exogenous populations of cells in patients, this system offers potential as a screening platform to improve cell-based therapy.
08:41
Ultrasound Velocity Measurement in a Liquid Metal Electrode
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Cited by 14 •
2015
Ultrasound velocimetry is used to study mixing by fluid flow in liquid metal electrodes. The focus of this manuscript is to illustrate the methods used for making precise, spatially-resolved ultrasound measurements while limiting oxidation and controlling and monitoring temperature, applied current, and the heater power being supplied.
FAQs
Hydrodynamic shear changes the forces acting on a cell, bead, or microsphere as fluid moves through a system. Surface adhesion can counter that motion, while weaker interactions may permit faster movement or loss of contact. Comparing velocities under these conditions helps researchers evaluate how fluid forces and interfacial attachment jointly govern behavior in a fluidic environment.
A transition from rolling to pausing suggests that surface interactions are temporarily restricting motion, whereas detachment indicates that contact can no longer be maintained. Tracking these changes alongside rolling velocities provides functional information about the strength or stability of interactions at the interface. This distinction helps separate continuous movement from intermittent or failed adhesion in fluidic experiments.
Receptor-ligand binding can alter how biological particles interact with a surface during motion. Stronger or more sustained binding may increase resistance to fluid-driven movement and promote pauses, while insufficient interaction may lead to continued rolling or detachment. Including this molecular context allows velocity measurements to characterize biological adhesion rather than treating motion as a purely physical response.
Researchers track the displacement of a cell, bead, or microsphere over a measured time interval while it remains in rolling contact with a surface. The resulting motion provides a velocity value that can be compared across fluidic conditions, surface types, or biological interactions. Observing trajectories also helps identify whether particles roll continuously, pause, or detach.
These measurements are useful when evaluating how cells or microspheres interact with engineered biomaterial interfaces. Differences in motion can reveal whether a surface supports, limits, or fails to maintain biological attachment under fluid flow. The resulting data help characterize surface performance and provide a functional comparison between biomaterial designs used in bioengineering studies.
In microfluidic systems, rolling behavior provides information about how particles move through regions intended for capture, retention, or sorting. Measuring displacement over time can show whether hydrodynamic shear and surface interactions produce the desired balance between transport and attachment. Researchers can use these observations to assess whether a design effectively handles biological targets under controlled fluidic conditions.