Charles Pederson
Charles Pederson - Related Videos
03:19
Gas Laws: Boyle's, Gay-Lussac, Charles', Avogadro's, and Ideal Gas Law
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2020
Through experiments, scientists established the mathematical relationships between pairs of variables, such as pressure and temperature, pressure and volume, volume and temperature, and volume and moles, that hold for an ideal gas. Pressure and Temperature: Gay-Lussac’s Law (Amontons’s Law) Imagine filling a rigid container attached to a pressure gauge with gas and then sealing the container so that no gas may escape. If the container is cooled, the gas inside likewise gets colder, and its...
07:06
Mouse Sperm Cryopreservation and Recovery using the I·Cryo Kit
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Cited by 5 •
2011
Here we demonstrate the newly developed I•Cryo kit for mouse sperm cryopreservation. Two-cell stage embryo development with frozen-thawed sperm was improved consistently in 5 mouse strains with the use of this kit. Over a 1.5 year period, 49 genetically modified mouse lines were archived by sperm cryopreservation with the I•Cryo kit and later successfully recovered by IVF.
02:30
Radiochemical Assessment of Glycogen Synthase Enzyme Activity in Animal Tissue
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2025
The animal tissue assay utilizes nuclear scintillation detection to determine the enzymatic activity of glycogen synthase by measuring the incorporation of radio-labeled glucose into glycogen.
08:05
Multiplexed Fluorometric ImmunoAssay Testing Methodology and Troubleshooting
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Cited by 19 •
2011
Using Luminex Corporation’s xMAP microsphere technology, we have developed the Multiplexed Fluorometric ImmunoAssay (MFIA) for serosurveillance of various laboratory animal species. The MFIA is a suspension microarray where antigen, tissue control or immunoglobulins are covalently linked to color-coded polystyrene microspheres. The MFIA testing method as well as various troubleshooting topics is addressed.
07:03
Large Scale Zebrafish-Based In vivo Small Molecule Screen
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Cited by 17 •
2010
Zebrafish has emerged as a powerful in vivo platform for phenotype-based drug screens and chemical genetic analysis. Here, we demonstrate a simple, practical method for large-scale screening of small molecules using zebrafish embryos.
FAQs
Binding occurs when a metal cation fits within the ring’s oxygen-lined cavity. The oxygen atoms provide the interaction sites, while the ring geometry positions them around the guest ion. This arrangement produces a host–guest complex without requiring a new conventional covalent bond, allowing chemists to study molecular recognition as a selective binding event.
Selectivity depends strongly on how closely the cavity dimensions match the size of the metal ion. A suitable match can support a stable host–guest complex, whereas poor size compatibility reduces effective binding. Solvent conditions also influence the outcome, so ion recognition cannot be predicted from cavity size alone.
Pedersen’s complexes demonstrate that a molecule can recognize and hold another species through interactions that do not rely on conventional covalent bonding. The crown ether acts as the host and the metal cation as the guest, creating a reversible molecular association whose stability and selectivity can be examined through structural fit and solvent-dependent behavior.
A practical evaluation compares the stability of host–guest complexes formed with different metal cations while considering cavity dimensions and solvent conditions. Researchers can then relate binding differences to the match between ion size and the oxygen-containing cavity. This approach connects molecular structure with selective recognition and provides a basis for comparing host performance.
The chemistry supports applications that depend on selective ion recognition, including ion separation, molecular sensing, catalysis, and the design of functional materials. In each case, crown ethers provide a host framework whose binding behavior can influence how ions are selected, transported, detected, or incorporated into a larger chemical system.
Pedersen’s research established crown ethers as an important class of synthetic host molecules and helped launch modern supramolecular chemistry. Its significance extends beyond one molecular structure because it supplied a way to investigate recognition and selective binding without conventional covalent bonds. He shared the 1987 Nobel Prize in Chemistry for these contributions.