Surfactant Application
Surfactant Application - Related Videos
09:34
Extraction and Characterization of Surfactants from Atmospheric Aerosols
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Cited by 26 •
2017
Methods are presented for the targeted extraction of surfactants present in atmospheric aerosols and the determination of their absolute concentrations and surface tension curves in water, including their Critical Micelle Concentration (CMC).
10:28
Experimental Measurement of Settling Velocity of Spherical Particles in Unconfined and Confined Surfactant-based Shear Thinning Viscoelastic Fluids
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Cited by 15 •
2014
This paper demonstrates the experimental procedure to measure terminal settling velocities of spherical particles in surfactant-based shear thinning viscoelastic fluids. Fluids over a wide range of rheological properties are prepared and settling velocities are measured for a range of particle sizes in unbounded fluids and fluids between parallel walls.
07:20
Lavage-induced Surfactant Depletion in Pigs As a Model of the Acute Respiratory Distress Syndrome (ARDS)
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Cited by 21 •
2016
Repeated pulmonary lavages in anesthetized pigs induce lung injury resembling major aspects of human acute respiratory distress syndrome (ARDS). For this purpose the lungs are repeatedly lavaged with 0.9% saline at 37 °C. The goal of the protocol is a reproducible mitigation of gas exchange and hemodynamics for research in ARDS.
06:22
Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)
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Cited by 5 •
2021
A combination of surfactant washout using 0.9% saline (35 mL/kg body weight, 37 °C) and high tidal volume ventilation with low PEEP to cause moderate ventilator induced lung injury (VILI) results in experimental acute respiratory distress syndrome (ARDS). This method provides a model of lung injury with low/limited recruitability to study the effect of various ventilation strategies for extended periods.
06:31
Studying Surfactant Effects on Hydrate Crystallization at Oil-Water Interfaces Using a Low-Cost Integrated Modular Peltier Device
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Cited by 2 •
2020
We present a protocol to study the formation of hydrates in the presence of nonionic surfactants on the interface of a water droplet submerged in cyclopentane. The protocol consists of building a low-cost, programmable, temperature regulator. The temperature control system is combined with visualization techniques and internal pressure measurements.
FAQs
Phospholipids form the primary surface-active layer at the alveolar air–liquid interface, while associated proteins contribute to the behavior of that layer. Together, these components reduce interfacial tension during breathing. Their coordinated action helps preserve alveolar stability, allowing the lungs to remain functional rather than repeatedly collapsing and reopening with each respiratory cycle.
Lower surface tension makes the alveoli easier to expand, which improves lung compliance, meaning the lungs can inflate with less mechanical difficulty. More stable alveoli also support the air–liquid interface needed for effective gas exchange. Consequently, an adequate surfactant layer connects physical stabilization of the alveoli with improved respiratory performance.
Treatment depends not only on placing surfactant in the airway but also on its ability to spread across relevant alveolar surfaces. Distribution determines how broadly the surface-active material can reduce interfacial tension and support alveolar stability. For this reason, surfactant composition and delivery are important considerations when developing safer and more effective pulmonary therapies.
In the clinical setting described, exogenous surfactant is administered into the trachea so it can reach the lungs and spread across alveolar surfaces. The procedure therefore links airway delivery with action at the alveolar air–liquid interface. Attention to both administration and subsequent distribution supports the intended improvements in lung compliance and gas exchange.
Premature infants with respiratory distress syndrome are the primary clinical group identified for this treatment. In these patients, pulmonary surfactant therapy is used to address impaired respiratory function by supplying exogenous surface-active material to the lungs. Its clinical relevance comes from the potential to improve lung compliance and gas exchange during a vulnerable period of development.
The principal outcomes are improved lung compliance and gas exchange, because these reflect whether the administered material is supporting alveolar function. Researchers also consider surfactant composition, delivery, and distribution when assessing treatment performance. These factors help guide safer respiratory care and inform development of surfactant-based approaches for acute and chronic lung disease.