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Chapters
- 00:05Title
- 01:13Introducer Sheath for Pulmonary Artery Catheter, Central Venous Line and Arterial Catherter Placement
- 03:02Pulmonary Artery Catheter (PAC) Introduction
- 04:05Pulmonary Artery Thermodilution Technique and Hemodynamic Measurements
- 04:52Surfactant Depletion by Lung Lavage
- 06:09Results: Representative PaO2/FIO2 Ratios and MPAP for Three Pigs
- 06:40Conclusion
Repeated pulmonary lavages in anesthetized pigs induce lung injury resembling major aspects of human acute respiratory distress syndrome (ARDS). For this purpose the lungs are repeatedly lavaged with 0.9% saline at 37 °C. The goal of the protocol is a reproducible mitigation of gas exchange and hemodynamics for research in ARDS.
Tags
Lavage-induced Surfactant DepletionAcute Respiratory Distress Syndrome (ARDS)Lung AtelectasisHypoxemiaPulmonary HypertensionRespiratory Mechanic DisturbancesThermodynamic ChangesSurfactant WashoutWarm SalinePigsEndotracheal Tube PlacementMechanical VentilationPartial Pressure Of Carbon Dioxide (PaCO2)Peripheral Oxygen Saturation
