U-shaped Notch
U-shaped Notch - Related Videos
08:01
Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Cited by 13 •
2017
Notch signaling is a form of cellular communication that relies upon direct contact between cells. To properly induce Notch signaling in vitro, Notch ligands must be presented to cells in an immobilized state. This protocol describes methods for in vitro stimulation of Notch signaling in mouse osteoclast precursors.
03:14
Notch Signaling Pathway
0 Views •
2021
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule. The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
03:14
Notch Signaling Pathway
0 Views •
2023
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule. The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
03:37
Molecular Shape and Polarity
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2020
Dipole Moment of a Molecule Polar covalent bonds connect two atoms with differing electronegativities, leaving one atom with a partial positive charge (δ+) and the other atom with a partial negative charge (δ–), as the electrons are pulled toward the more electronegative atom. This separation of charge gives rise to a bond dipole moment. The magnitude of a bond dipole moment is represented by the Greek letter mu (µ) and is given by the formula shown here, where Q is the magnitude of the...
09:03
Morphometric Analyses of Shape: The Analysis Software Toolbox for Craniofacial Shape Quantification in Zebrafish
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2026
This work describes a protocol for quantifying craniofacial cartilage shape using free software (tpsDigs2, MorphoJ, and PAST) to measure changes in facial structure in zebrafish larvae.
FAQs
Loading causes stress to flow around the curved cutout rather than remain uniformly distributed. The highest local stress develops near the notch root, where the geometry redirects the stress path. Engineers describe the severity of this amplification with a stress-concentration factor, which helps connect the notch shape to possible crack initiation and structural performance.
The radius controls how abruptly the component geometry changes at the notch root. A rounded profile generally produces less stress concentration than a sharp notch, making radius an important variable in durability studies. Comparing different radii allows engineers to examine how geometric smoothness affects local stress, crack initiation, and the reliability of a component.
Peak stress depends on more than the curved root alone. Notch depth and the material surrounding the cutout also affect how stress is distributed through the component. Holding other conditions consistent while changing these geometric or material features helps engineers determine how the stress-concentration factor responds and which configurations may be more vulnerable under loading.
The key comparison is the severity of local stress concentration produced by each profile. Because the rounded U-shaped form generally reduces concentration relative to a sharp notch, it can provide a controlled geometry for examining the effect of notch shape. This comparison supports engineering assessments of how local geometry influences durability and structural reliability.
Engineers incorporate the geometry into test specimens to create a controlled discontinuity whose radius and depth can be specified. Under loading, the specimen reveals how the local stress field relates to crack initiation or fracture behavior. Using comparable notch geometries helps researchers evaluate material performance and distinguish geometric effects from differences observed during testing.
Results can indicate how a component or material responds when stress concentrates at a rounded root. In fatigue and fracture studies, observations of crack initiation and related failure behavior help engineers assess durability. These findings support comparisons among materials or geometries and contribute to judgments about structural reliability in components containing similar controlled discontinuities.