Liver Mri
Liver Mri - Related Videos
06:06
Optogenetic Functional MRI
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Cited by 15 •
2016
This protocol describes the steps and data analysis required to successfully perform optogenetic functional magnetic resonance imaging (ofMRI). ofMRI is a novel technique that combines high-field fMRI readout with optogenetic stimulation, allowing for cell type-specific mapping of functional neural circuits and their dynamics across the whole living brain.
12:35
In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion
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Cited by 14 •
2011
The study of liver sinusoidal endothelial cells (SECs) must be performed with primary cells obtained from the animal as no cell lines exist. This method relies on liver digestion and differential centrifugation for SEC purification for subsequent culturing and experimentation.
08:20
MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
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Cited by 31 •
2015
Here we outline the procedure for MRI-guided repetitive transcranial magnetic stimulation to the dorsomedial prefrontal cortex as an experimental treatment for major depressive disorder.
12:13
Ex Situ Normothermic Machine Perfusion of Donor Livers
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Cited by 21 •
2015
Here we present a protocol describing oxygenated ex situ machine perfusion of donor liver grafts. This article contains a step by step protocol to procure and prepare the liver graft for machine perfusion, prepare the perfusion fluid, prime the perfusion machine and perform oxygenated normothermic machine perfusion of the liver graft.
06:58
Synthesis of an In vivo MRI-detectable Apoptosis Probe
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Cited by 3 •
2012
Early detection of apoptosis may identify at-risk cell populations in a variety of diseases. Here we demonstrate a method to link an early apoptosis-detection protein (Annexin V) to a MRI-detectable iron oxide nanoparticle (SPIO). This method may be extended to other proteins of interest to generate MRI-detectable molecular imaging probes.
FAQs
Hydrogen nuclei respond to the magnetic field and emit signals as they return to equilibrium. MRI sequences process these signals in different ways, producing T1-weighted, T2-weighted, and diffusion-weighted images. Comparing these image types helps distinguish anatomical and functional characteristics within liver tissue, supporting more detailed assessment than relying on a single image contrast.
T1- and T2-weighted sequences provide complementary high-contrast views of liver anatomy and tissue characteristics, while diffusion-weighted imaging adds functional information related to signal behavior within tissue. Using these sequences together gives clinicians multiple perspectives for evaluating focal liver abnormalities and broader changes associated with disease.
Some examinations include a gadolinium-based contrast agent to enhance the information obtained from the MRI sequences. Contrast enhancement can support characterization of focal liver lesions and improve assessment of blood vessels and related tissue patterns. Its use is therefore an optional component of selected studies rather than a requirement for every liver examination.
Liver MRI offers multiplanar detail that can complement findings from ultrasound and computed tomography. This additional imaging perspective may help characterize liver lesions, evaluate tissue changes, and visualize vessels or bile ducts. It also provides these detailed images without ionizing radiation, which distinguishes it from imaging methods that use radiation.
Clinical applications include assessing cirrhosis, fatty liver disease, iron accumulation, and fibrosis, as well as characterizing focal lesions. The resulting tissue and anatomical information can show patterns relevant to several liver disorders. Its value lies in combining detailed structural views with sequence-based information for a more comprehensive evaluation.
By characterizing focal lesions and depicting liver tissue, blood vessels, and bile ducts, Liver MRI supplies information relevant to cancer assessment. These findings can contribute to staging and treatment planning by clarifying the appearance and anatomical context of abnormalities. The multiplanar images may also complement other examinations used in the overall diagnostic evaluation.