Ultrasound Thrombus Detection
Ultrasound Thrombus Detection - Related Videos
08:50
Thrombus Profiling Assay: A Microfluidics-Based Platform for Comprehensively Characterizing Biomechanical Thrombogenesis
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2026
This work describes a microfluidic assay that uses shear stress to trigger thrombus formation in blood and characterizes the thrombus by multiple dimensions of readout. The assay can measure the prothrombotic tendency of blood samples, and is thus useful in disease diagnosis, drug discovery, as well as basic mechanistic studies related to thrombosis.
09:01
Intravital Microscopy and Thrombus Induction in the Earlobe of a Hairless Mouse
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Cited by 4 •
2017
The ear model of the hairless SKH1-Hrhr mouse enables intravital fluorescence microscopy of microcirculation and phototoxic thrombus induction without prior surgical preparation in the examined microvascular bed. Therefore, the ear of the hairless mouse is an excellent in vivo model to study the complex interactions during microvascular thrombus formation, thrombus evolution, and thrombolysis.
05:54
Intravital Fluorescence Microscopy to Study Microvascular Thrombus Formation
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2025
This video demonstrates the intravital fluorescence microscopy technique to study thrombus formation in a mouse model. The mouse is injected with a fluorophore-labeled polysaccharide to monitor blood circulation. Upon illumination with a high-intensity light, the phototoxic induction of an injury in the microvasculature of the ear leads to the formation of a thrombus, which is confirmed by visualizing the obstruction in the blood flow.
02:05
Visualization of a Cerebral Thrombus in a Mouse Using Micro-Computed Tomography Imaging
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2025
Source: Kim, D., et. al. Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli. J. Vis. Exp. (2016)This video demonstrates visualization of cerebral thrombus in mice using micro-computed tomography (micro-CT) imaging. A cerebral thrombus mouse model is injected with fibrin-targeted gold nanoparticles acting as a contrasting agent. The mouse is placed on the bed of a micro-CT machine, and images are acquired from multiple angles.
11:18
Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice
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Cited by 29 •
2013
Here we report an experimental technique of fluorescence intravital microscopy to visualize heterotypic platelet-neutrophil interactions on the activated endothelium during vascular inflammation and thrombus formation in live mice. This microscopic technology will be valuable to study the molecular mechanism of vascular disease and to test pharmacologic agents under pathophysiological conditions.
FAQs
The key finding is failure of a vein to collapse under probe pressure. In a normal vein, compression narrows the lumen, while thrombus within the vessel prevents this response. This mechanical difference gives clinicians a direct way to distinguish a potentially clotted segment from a patent vein during examination, complementing visual and flow-related findings.
B-mode imaging can display material occupying the vessel lumen, whereas Doppler techniques evaluate blood movement around that area. Reduced or absent flow supports the presence of an obstructive clot and shows its effect on circulation. Using structural and flow information together provides a more complete assessment than relying on only one imaging feature.
A thrombus can alter the amount of blood moving through the affected vessel. Doppler examination helps identify reduced or absent flow around the clot, adding functional information to the structural assessment. This is clinically relevant because the examination can address both whether intraluminal material is present and how that material affects vascular flow.
The examination combines probe compression with imaging of the vessel. Clinicians assess whether the vein collapses, inspect the lumen with B-mode imaging, and use Doppler techniques to evaluate flow around the suspected abnormality. These complementary steps provide real-time information about the vessel and help identify segments where a thrombus may be affecting circulation.
It is particularly useful when deep vein thrombosis is suspected and clinicians need information to support urgent decisions. The method can be performed without ionizing radiation and is accessible for bedside assessment, making it valuable in emergency medicine. It also supports evaluation of vascular disease over time through repeated, real-time examinations.
Ultrasound thrombus detection can show the clot's position within a vessel and indicate whether flow is reduced or absent around it. The examination therefore provides both anatomical and functional information. Because it is noninvasive and does not use ionizing radiation, clinicians can use it for bedside diagnosis and longitudinal monitoring when repeated assessment is relevant.