Fluid Percussion Injury
Fluid Percussion Injury - Related Videos
03:12
Generating a Mouse Model of Traumatic Brain Injury Using a Lateral Fluid Percussion Device
0 Views •
2025
The video demonstrates a method to generate a mouse model of traumatic brain injury (TBI) using a lateral fluid percussion device (LFPI). Upon anesthetizing the mouse, the brain is exposed by creating a window on the skull. A saline-filled cannula is attached to the window and is then connected to the LFPI. The pendulum of the device is released to create a pressure pulse that inflicts a traumatic brain injury.
05:03
Induction of Traumatic Brain Injury in a Rat Model Using a Lateral Fluid Percussion Device
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2025
This video demonstrates the induction of traumatic brain injury (TBI) in a rat using a lateral fluid percussion injury (FPI) device. The procedure involves creating a hole in the skull of an anesthetized rat to expose the dura mater, onto which a cannula is attached. The rat is then connected to the device, which generates a pressure wave that reaches the brain, mimicking TBI by causing neural cell death and vascular...
11:04
Lateral Fluid Percussion: Model of Traumatic Brain Injury in Mice
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Cited by 125 •
2011
Lateral fluid percussion (LFP), an established model of traumatic brain injury in mice, is demonstrated. LFP fulfills three major criteria for animal models: validity, reliability and clinical relevance. The procedure, consisting of surgical craniotomy, fixation of hub followed by induction of injury, resulting in focal and diffuse injuries, is described.
05:16
Maintenance of a Lateral Fluid Percussion Injury Device
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Cited by 3 •
2023
Proper care and maintenance are essential for a lateral fluid percussion injury (LFPI) device to function reliably. Here, we demonstrate how to properly clean, fill, and assemble an LFPI device, and ensure that it is adequately maintained for optimal results.
08:45
Percussion
0 Views •
2023
Source: Jaideep S. Talwalkar, MD, Internal Medicine and Pediatrics, Yale School of Medicine, New Haven, CT Simply stated, percussion refers to the striking of one object against another to produce sound. In the early 1700s, an Austrian inn-keeper's son, named Leopold Auenbrugger, discovered that he could take inventory by tapping his father's beer barrels with his fingers. Years later, while practicing medicine in Vienna, he applied this technique to his patients and published the first...
FAQs
Injury severity provides a controlled way to compare traumatic brain injury outcomes. By examining different levels of induced damage, researchers can relate the initial mechanical insult to later changes such as neuroinflammation, edema, neuronal loss, and behavioral deficits. This comparison helps distinguish responses that vary with injury magnitude and supports systematic evaluation of disease mechanisms.
The initial pressure pulse produces primary mechanical damage, while secondary processes develop afterward. Neuroinflammation, edema, neuronal loss, and behavioral deficits represent consequences that can be studied beyond the immediate insult. Separating these stages allows neuroscience researchers to investigate how early tissue damage relates to later dysfunction and to identify processes that may be relevant to treatment.
These components create a defined path for force transmission. A pendulum-driven piston generates the pressure wave in the fluid-filled reservoir, the connected cranial port carries that wave toward the brain, and the exposed dura receives the transmitted force over the underlying neural tissue. Their arrangement enables researchers to produce controlled damage for experimental comparison.
The procedure begins with access to the dura and connection of a cranial port to a fluid-filled reservoir. A pendulum then drives a piston, producing a brief pressure pulse in the reservoir. That pulse travels through the port and acts on the exposed dura and underlying neural tissue, after which researchers assess injury-related biological or behavioral outcomes.
Researchers use Fluid Percussion Injury when they need an experimental system for investigating traumatic brain injury mechanisms, examining secondary responses, or comparing outcomes across controlled injury severities. The model is also useful for evaluating potential treatments and exploring biomarkers associated with recovery. Its value comes from linking a defined mechanical insult with measurable biological and behavioral consequences.
Studies can use this model to examine several levels of traumatic brain injury response, including neuroinflammation, edema, neuronal loss, and behavioral deficits. Researchers can also investigate biomarkers associated with recovery and assess whether potential treatments alter injury-related outcomes. Together, these measurements connect tissue-level changes with functional consequences relevant to neuroscience research.