Midline Cortical Structures
Midline Cortical Structures - Related Videos
10:36
Juxtasomal Biocytin Labeling to Study the Structure-function Relationship of Individual Cortical Neurons
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Cited by 22 •
2014
To understand the structure of neuronal networks, functional and morphological characterization of individual neurons is a necessity. Here, we demonstrate juxtasomal biocytin labeling, which allows electrophysiological recordings in the extracellular configuration, yet maintaining the ability to intracellularly label the neuron for post hoc reconstruction of dendritic and axonal architecture.
09:00
Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex
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Cited by 3 •
2015
Stereotactic Electroencephalography (SEEG) is an operative technique used in epilepsy surgery to help localize seizure foci. It also affords a unique opportunity to investigate brain function. Here we describe how SEEG can be used to investigate cognitive processes in human subjects.
11:25
Isolation and Culture of Mouse Cortical Astrocytes
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Cited by 460 •
2013
Astrocytes have been recognized to be versatile cells participating in fundamental biological processes that are essential for normal brain development and function, and central nervous system repair. Here we present a rapid procedure to obtain pure mouse astrocyte cultures to study the biology of this major class of central nervous system cells.
09:09
Cortical Actin Flow in T Cells Quantified by Spatio-temporal Image Correlation Spectroscopy of Structured Illumination Microscopy Data
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Cited by 17 •
2015
To investigate flow velocities and directionality of filamentous-actin at the T cell immunological synapse, live-cell super-resolution imaging is combined with total internal reflection fluorescence and quantified with spatio-temporal image correlation spectroscopy.
06:41
Astrocyte Isolation: A Method to Obtain Pure Preparation of Mouse Cortical Astrocytes
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2023
In this video, we describe the method to obtain a pure preparation of astrocytes from newly born mice.
FAQs
Local circuitry shapes how each midline region contributes to behavior, while communication with connected cortical and subcortical networks integrates those contributions. This organization helps explain why motivation, emotion, attention, memory, self-related processing, and motor control are not isolated functions. Studying both levels therefore links activity within a region to broader cognitive and behavioral patterns.
Their medial arrangement creates an anatomical axis that helps organize relationships among cortical areas involved in cognition and behavior. Considering the cingulate cortex, medial prefrontal cortex, precuneus, and paracentral lobule together can clarify how structural position relates to functions such as attention, memory, self-related processing, and motor control. This framework supports interpretation beyond any single region.
Their contributions span motivation, emotion, attention, memory, self-related processing, and motor control because regional activity is shaped by both local circuitry and network communication. The same anatomical system can therefore participate in multiple aspects of behavior without implying that one region performs every function independently. This integrated perspective is important when relating cortical activity to cognition.
Researchers use the anatomical relationships among these medial regions to organize and interpret neuroimaging results. Findings can be considered in relation to the cingulate cortex, medial prefrontal cortex, precuneus, and paracentral lobule, as well as their connected cortical and subcortical networks. This approach helps connect observed activity with cognition, behavior, and regional organization.
Studying these regions provides an anatomical and functional framework for examining how brain injury or epilepsy relates to behavior and cognition. Researchers can consider affected midline areas alongside their network connections and associated functions, including emotion, attention, memory, motivation, self-related processing, and motor control. The goal is to relate structural or functional disruption to integrated outcomes.
They are relevant because their organization links cortical anatomy, network communication, and functions that develop into complex behavior and cognition. Examining these regions in neurodevelopmental disorders can help researchers relate differences in anatomical relationships or activity to domains such as attention, memory, emotion, self-related processing, and motor control, while preserving a network-level interpretation.