Receptor Transporting Protein
Receptor Transporting Protein - Related Videos
14:32
Real-time Analyses of Retinol Transport by the Membrane Receptor of Plasma Retinol Binding Protein
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Cited by 11 •
2013
Here we describe an optimized technique to produce high-quality vitamin A/RBP complex and two real-time monitoring techniques to study vitamin A transport by STRA6, the RBP receptor.
01:24
Protein Transport to the Stroma
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2023
Chloroplasts are triple membrane structures with an outer membrane, an inner membrane, and a thylakoid membrane, each containing distinct metabolite transporters, membrane translocons, and enzymes. Appropriate sorting and translocating these proteins to their correct membrane systems is essential for chloroplast function. Protein complexes called the translocon of the outer chloroplast membrane or TOC complex, and the translocon of the inner chloroplast membrane or TIC complex mediate the...
01:22
Protein Transport to the Thylakoids
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2023
Thylakoids are membrane-bound sac-like structures within the chloroplast that serve as sites for photosynthesis. Thylakoid lumen contains many electron transport proteins and is enclosed by a thylakoid membrane rich in the light-harvesting complex. Proteins targeted to the thylakoids are transported as precursors and are sorted by the general TOC/TIC import pathway. Once the precursor reaches the stroma, stromal processing peptidases remove their transit signal and expose thylakoid signal...
11:45
Quantifying Agonist Activity at G Protein-coupled Receptors
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Cited by 10 •
2011
A method for estimating the affinity constant of an agonist for the active state (Kb) of a G protein-coupled receptor is described. The analysis provides absolute or relative measures of Kb depending on whether constitutive receptor activation is measurable. Our method applies to various responses downstream from receptor activation.
01:27
G-protein Coupled Receptors
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2021
G-protein-coupled receptors are ligand-binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that traverses the cell membrane seven times, creating intracellular and extracellular loops. The extracellular loops create a ligand-specific pocket which binds to neurotransmitters or hormones. The intracellular loops hold onto the G-protein.The G-protein, or guanine nucleotide-binding protein, is a large heterotrimeric complex. Its three subunits...
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Vesicles provide membrane-bound carriers, while the cytoskeleton provides routes through the cell. Together, these systems help direct receptors toward particular neuronal regions rather than distributing them randomly. This spatial control allows receptors to reach axons, dendrites, or synaptic membranes, where their placement can influence how effectively neurons detect and respond to signals.
Recycling returns receptors to functional membrane locations after they have been removed, helping regulate receptor availability over time. In contrast, receptor removal decreases the number of receptors present at a signaling site. The balance between these outcomes changes receptor abundance at synapses and therefore affects neurotransmission and the capacity of synapses to adapt.
Receptor trafficking must be spatially directed so that receptors arrive at the neuronal compartment where they are needed. Receptor transporting proteins help organize movement toward axons, dendrites, or synaptic membranes, linking intracellular transport with neuronal architecture. Correct localization supports compartment-specific signaling and helps maintain communication between connected neurons.
When receptor trafficking is disrupted, receptors may not reach, remain at, or return to the locations required for signaling. Such changes can alter receptor abundance at synapses, affecting neurotransmission and synaptic plasticity. Because these processes contribute to signaling and connectivity, abnormal trafficking can provide insight into mechanisms underlying neurological disorders.
Studying these proteins can clarify how neurons control receptor placement and availability during communication. Their activity connects intracellular movement with neurotransmission, synaptic plasticity, and signaling between neurons. This makes receptor transport a useful framework for examining how cellular organization supports normal neural function rather than treating synaptic responses as isolated membrane events.
They are relevant because changes in receptor delivery, recycling, or removal can modify the receptor population present at a synapse. That population influences how strongly a synapse responds and how its signaling properties change. Investigating this transport therefore helps researchers connect molecular trafficking processes with plasticity, the capacity of synaptic communication to adjust.