Silicon Probe Implantation
Silicon Probe Implantation - Related Videos
17:37
Large-scale Recording of Neurons by Movable Silicon Probes in Behaving Rodents
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Cited by 111 •
2012
We describe methods for large-scale recording of multiple single units and local field potential in behaving rodents with silicon probes. Drive fabrication, probe attachment to the drive and probe implantation processes are illustrated in sufficient details for easy replication.
03:47
Implantation of a Flexible Biocompatible Probe in a Glioblastoma Mouse Model
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2025
Source: Lefevre, M. C., et al., Flexible Organic Electronic Devices for Pulsed Electric Field Therapy of Glioblastoma. J. Vis. Exp. (2022)This video demonstrates the implantation of a flexible, biocompatible probe in a glioblastoma mouse model to deliver targeted pulsed electric field therapy for neurotherapeutic applications.
03:22
Recording Brain Electrical Activity in Behaving Mice Using Multi-Shank Linear Silicon Probes
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2025
This video outlines a protocol for implanting a multi-shank linear silicon probe into the mouse brain to measure local field potentials. The procedure involves securing the probe to a stereotaxic unit, positioning it accurately over the target brain region, inserting it into the brain, and securing it with dental cement. After implantation, the assembly is protected with a casing. Following recovery, the setup allows for recording local field potentials, providing insights into neuronal...
09:59
Implantation of Chronic Silicon Probes and Recording of Hippocampal Place Cells in an Enriched Treadmill Apparatus
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Cited by 9 •
2017
We describe the diverse steps to implant chronic silicon probes and to record place cells in mice that are running head-fixed on a cue-enriched treadmill apparatus.
05:45
Recording Large-scale Neuronal Ensembles with Silicon Probes in the Anesthetized Rat
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Cited by 24 •
2011
Extracellular recordings of neuronal activity using silicon probes in the anesthetized rat will be described. This technique allows information to be obtained across multiple brain areas from more than 100 neurons simultaneously. It provides information with single cell resolution about neuronal ensembles dynamics in multiple local circuits.
FAQs
Recording sites measure extracellular voltage changes in the tissue surrounding the implanted shank. Because each site samples activity near its position, the resulting signals can be compared across locations to examine how neural activity varies among neighboring regions or layers. This spatially organized sampling helps investigators relate electrical patterns to local circuit function and behavior.
The shank provides a defined physical arrangement for the recording and stimulation sites. Its geometry helps position electrodes at selected brain regions and layers, allowing researchers to associate measured activity with anatomical location. Consistent site placement also supports comparisons across neural populations, circuit zones, and experimental conditions when examining how activity is organized.
Recording observes voltage changes arising near the electrode sites, whereas stimulation uses selected electrodes to deliver electrical input to the surrounding tissue. The two functions therefore support complementary experiments: one characterizes ongoing neural activity, and the other tests how changing activity influences circuits or behavior. Using both capabilities can connect neural signals with functional effects.
The procedure requires a cranial opening through which the silicon probe is inserted into brain tissue. The shank is positioned so its defined electrode geometry reaches the intended region or layers, after which recording sites can monitor extracellular voltage and selected electrodes can provide stimulation. The placement determines which neural populations and circuit locations are sampled.
Researchers use this approach when they need to relate neural activity to circuit operation, sensory processing, behavior, or neurological disease. Its arranged electrode sites allow activity to be examined at targeted locations while experiments address how signals change across regions or layers. The same platform can also support studies that test the effects of electrical stimulation.
Data from these implants can help link cellular-level electrical activity with broader functions such as behavior and sensory processing. In disease research, the measurements provide a way to examine abnormal or altered circuit activity. The technology also contributes to brain-computer interfaces and other neurotechnologies by combining neural signal measurement with the possibility of electrical influence.