Tumor Morphology
Tumor Morphology - Related Videos
03:07
Morphological and Physiological Monitoring of Tumor Spheroids Using Optical Coherence Tomography
0 Views •
2025
Source: Huang, Y. et. al., Longitudinal Morphological and Physiological Monitoring of Three-dimensional Tumor Spheroids Using Optical Coherence Tomography. J. Vis. Exp. (2019)This video demonstrates the use of optical coherence tomography (OCT) to monitor tumor spheroids in a multi-well plate by capturing high-resolution cross-sectional images. By analyzing light reflections from cellular structures, OCT constructs 3D models to assess morphological features like size and shape while also...
09:03
Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
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Cited by 7 •
2014
We describe a matrigel plug assay to illustrate angiogenic potential of a pool of factors secreted by cancer cells using two complementary imaging modalities, ultrasound and endomicroscopy. The matrigel, an extracellular matrix (ECM)-mimic gel, is utilized to introduce the host (mouse) with angiogenic factors secreted to the conditioned media...
09:36
Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
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Cited by 61 •
2010
Our protocol describes how to dissect the rat abdominal mammary gland and how to prepare mammary gland whole mounts. It also describes how to analyze mammary gland morphology using three end-points (number of terminal end buds, epithelial elongation and differentiation) and to use these results to predict mammary cancer risk in rats which were exposed to dietary modifications in utero or during prepuberty.
08:50
Longitudinal Morphological and Physiological Monitoring of Three-dimensional Tumor Spheroids Using Optical Coherence Tomography
0 Views •
Cited by 10 •
2019
Optical coherence tomography (OCT), a three-dimensional imaging technology, was used to monitor and characterize the growth kinetics of multicellular tumor spheroids. Precise volumetric quantification of tumor spheroids using a voxel counting approach, and label-free dead tissue detection in the spheroids based on intrinsic optical attenuation contrast, were demonstrated.
01:29
Microbial Morphologies
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2025
Bacterial and archaeal cells exhibit remarkable diversity in shape and structure, critical in their adaptability and functionality. Among bacteria, the most commonly observed shapes include cocci and bacilli. Cocci are spherical and may exist singly or in groupings such as pairs (diplococci), chains (streptococci), clusters (staphylococci), or tetrads. Bacilli, in contrast, are rod-shaped and can also occur as single cells, in pairs, or chains, depending on their environmental and genetic...
FAQs
Boundary characteristics and invasion patterns help distinguish a confined lesion from one that extends into surrounding brain regions. A sharply defined edge may be interpreted differently from tissue infiltration, because invasion can indicate interaction with nearby neural structures and potential disruption of local organization. Recording these features adds biological context to size and shape when assessing tumor behavior.
Cellular arrangement shows how tumor cells are organized within the tissue, while vascular patterns describe the lesion’s associated blood-vessel architecture. Examining both features can separate tumors that appear similar in overall size or shape and can contribute to classification. In neuroscience, these patterns also provide structural clues for studying how abnormal tissue relates to the surrounding brain.
Comparing neurological imaging with microscopic examination provides information at complementary scales. Imaging shows the lesion’s position, extent, and relationship to surrounding brain regions, whereas stained tissue reveals cellular organization and tissue architecture more directly. Agreement or differences between these views can refine interpretation, helping researchers connect an observable lesion with its cellular features and possible effects on neural circuits.
Assessment typically begins with neurological imaging to examine the lesion in the brain, followed by microscopic evaluation of stained tissue. Investigators then consider size, shape, boundaries, cellular arrangement, vascular patterns, and invasion together rather than relying on one feature. This integrated workflow supports consistent comparison among lesions and links structural observations with tumor classification.
Researchers should document both global and local characteristics: overall size and shape, the clarity of boundaries, the arrangement of cells, vascular patterns, and evidence of extension into neighboring brain regions. Considering these observations as a set reduces the risk of interpreting one isolated feature out of context. The resulting profile can support diagnosis and tumor classification.
Within neuroscience, structural analysis connects tumor pathology with brain function. Mapping invasion and tissue architecture against neural regions can help researchers investigate how abnormal growth and local infiltration influence neural circuits. Clinically oriented analyses also contribute to treatment planning, while research studies use these observations to examine disease progression and tumor interactions with the nervous system.