Metabolic Surgery
Metabolic Surgery - Related Videos
12:13
Considerations for Rodent Surgery
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2016
Source: Kay Stewart, RVT, RLATG, CMAR; Valerie A. Schroeder, RVT, RLATG. University of Notre Dame, IN The Guide for the Care and Use of Laboratory Animals1 dictates that rodent survival surgery be performed aseptically. Aseptic technique utilizes specific practices that minimize the contamination of the surgical site, including patient preparation, surgeon preparation, sterilization of instruments and other supplies, and the use of a clean and controlled environment. Presurgical planning,...
05:41
Metabolic Profile Analysis of Zebrafish Embryos
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Cited by 42 •
2013
Zebrafish represent a powerful vertebrate model that has been under-utilised for metabolic studies. Here we describe a rapid way to measure the in vivo metabolic profile of developing zebrafish that allows the comparison of different mitochondrial function parameters between genetically or pharmacologically manipulated embryos, thereby increasing the applicability of this organism.
00:52
What is Metabolism?
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2019
Overview Metabolism represents all of the chemical activity in a cell, including reactions that build molecules (anabolism) and those that break molecules down (catabolism). Anabolic reactions require energy, whereas catabolic reactions provide it. Thus, metabolism describes how cells transform energy through a variety of chemical reactions, which are often made more efficient with the help of enzymes. Metabolism Is the Sum of All of the Chemical Reactions That Take Place in an Organism
10:19
An Introduction to Cell Metabolism
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2023
In cells, critical molecules are either built by joining together individual units like amino acids or nucleotides, or broken down into smaller components. Respectively, the reactions responsible for this are referred to as anabolic and catabolic. These reactions require or produce energy typically in the form of a “high-energy” molecule called ATP. Together, these processes make up “Cell Metabolism,” and are hallmarks of healthy, living cells.JoVE’s introduction to cell metabolism briefly...
08:28
Metabolic Labeling
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2023
Metabolic labeling is used to probe the biochemical transformations and modifications that occur in a cell. This is accomplished by using chemical analogs that mimic the structure of natural biomolecules. Cells utilize analogs in their endogenous biochemical processes, producing compounds that are labeled. The label allows for the incorporation of detection and affinity tags, which can then be used to elucidate metabolic pathways using other biochemical analytical techniques, such as SDS-PAGE...
FAQs
Its effects extend beyond reducing stomach capacity. Changes in gastrointestinal anatomy modify the timing and pattern of nutrient delivery, which can alter satiety signals and gut hormone release. These shifts help explain sustained changes in appetite and energy balance, while also providing a physiological basis for studying how gastrointestinal signals influence metabolic disease.
GLP-1 and PYY are gut hormones linked to appetite regulation and glucose control. Metabolic surgery can alter signaling through these pathways, helping connect gastrointestinal changes with increased satiety and improved glycemia. Their involvement is pharmacologically important because endogenous hormone responses may reveal mechanisms that could be reproduced or modified through nonsurgical treatments.
Changes in intestinal nutrient flow can affect bile acid signaling, adding another mechanism beyond altered stomach capacity and gut hormone release. This signaling is relevant to metabolic outcomes because it contributes to the relationship between gastrointestinal function, insulin sensitivity, and energy regulation. Studying it helps researchers explain why the procedures affect several metabolic pathways at once.
Improved glycemia may reduce the need for medications used to manage obesity-associated type 2 diabetes, and some patients experience diabetes remission. The reduction in treatment requirements is a clinically important outcome rather than merely a change in body weight. It also gives pharmacologists a measurable way to evaluate how altered gastrointestinal signaling affects glucose control.
The procedures create a human model for examining endogenous pathways that regulate appetite, glucose control, and energy balance. By observing changes in gut hormones, bile acid signaling, insulin sensitivity, and medication requirements, researchers can connect physiological mechanisms with clinical outcomes. This model supports investigation of how naturally occurring signals might be targeted therapeutically.
Research focuses on identifying which physiological responses contribute most strongly to sustained weight loss and metabolic improvement. Gut hormone activity, bile acid signaling, and changes in insulin sensitivity provide candidate mechanisms for therapeutic development. The goal is to translate useful effects of the procedures into safer nonsurgical approaches for obesity and metabolic disease.