Nanoprecipitation
Nanoprecipitation - Related Videos
06:47
Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
0 Views •
Cited by 16 •
2011
This article describes a nanoprecipitation method to synthesize polymer-based nanoparticles using diblock co-polymers. We will discuss the synthesis of diblock co-polymers, the nanoprecipitation technique, and potential applications.
10:12
Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
0 Views •
Cited by 72 •
2019
Flash NanoPrecipitation (FNP) is a scalable approach to produce polymeric core-shell nanoparticles. Lab-scale formulations for the encapsulation of hydrophobic or hydrophilic therapeutics are described.
06:57
Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation
0 Views •
Cited by 24 •
2018
Nanomaterials provide versatile mechanisms of controlled therapeutic delivery for both basic science and translational applications, but their fabrication often requires expertise that is unavailable in most biomedical laboratories. Here, we present protocols for the scalable fabrication and therapeutic loading of diverse self-assembled nanocarriers using flash nanoprecipitation.
09:03
Manufacture and Drug Delivery Applications of Silk Nanoparticles
0 Views •
Cited by 49 •
2016
Nanoparticles are emerging as promising drug delivery systems for a broad range of indications. Here, we describe a simple yet powerful method to manufacture silk nanoparticles using reverse engineered Bombyx mori silk. These silk nanoparticles can be readily loaded with a therapeutic payload and subsequently explored for drug delivery applications.
FAQs
Rapid solvent displacement lowers the solubility of polymers or hydrophobic compounds as the organic phase meets the miscible antisolvent. This change creates conditions for nucleation, followed by assembly into nanoscale particles. The balance between these events influences the resulting particle population, making solvent exchange central to controlling formulation structure and consistency.
Mixing conditions influence how quickly the organic phase encounters the antisolvent and how uniformly solvent displacement occurs. These effects can change particle size and the breadth of the particle-size distribution. More controlled mixing therefore supports more consistent formulations, while poorly controlled conditions may produce greater variation in the nanoscale particle population.
Solvent composition helps determine the solubility change that drives nucleation and particle assembly, whereas stabilizers influence how the newly formed particles remain dispersed. Adjusting these formulation variables can affect particle size, distribution, and dispersion quality. Together, they help researchers tune nanoprecipitation formulations for more reliable delivery or functional performance.
A basic workflow begins by dissolving the selected polymer or hydrophobic compound in an organic phase, then rapidly mixing that phase with a miscible antisolvent. Solvent displacement promotes nucleation and particle assembly, after which formulation variables such as mixing conditions, solvent composition, and stabilizer content can be adjusted to improve dispersion and consistency.
Researchers can modify mixing conditions, solvent composition, and stabilizer selection or content to tune particle formation and dispersion. These changes may improve encapsulation and help produce delivery systems with more consistent properties. In bioengineering, such control is useful when formulation performance depends on how effectively therapeutic materials are incorporated and delivered.
Nanoprecipitation is useful for preparing drug-delivery systems, imaging agents, and other functional nanomaterials. Its value comes from the ability to adjust formulation parameters while producing nanoscale particles from polymers or hydrophobic compounds. This tunability supports biomedical research and therapeutic development by enabling platforms with controlled particle properties, dispersion, encapsulation, and delivery performance.
Researchers can assess particle size, particle-size distribution, dispersion, encapsulation, and delivery performance. These outcomes indicate how formulation choices affected nucleation, assembly, and the stability of the resulting particle system. Evaluating them helps identify conditions that produce more consistent platforms for therapeutic materials, imaging applications, or other bioengineering uses.