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Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
JoVE Journal
Bioengineering
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JoVE Journal Bioengineering
Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

DOI:
10.3791/58757-v

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10:12 min

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January 07, 2019

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, , , ,
1Department of Chemical and Biological Engineering,Princeton University

Chapters

  • 00:04Title
  • 00:51Encapsulation of Hydrophobic Compounds in Polymeric Nanoparticles (NPs) Using a Confined Impinging Jet (CIJ) Mixer
  • 04:08Encapsulation of Ovalbumin in Inverted NPs Using a Small-Scale Multi-Inlet Vortex Mixer (MIVM)
  • 06:44Modifications for Larger-Scale Formulation
  • 07:33Results: Flash NanoPrecipitation (FNP) of Polymeric Nanoparticles with Hydrophobic and Hydrophilic Cores
  • 09:08Conclusion

Summary

Automatic Translation

Automatic Translation

Flash NanoPrecipitation (FNP) is a scalable approach to produce polymeric core-shell nanoparticles. Lab-scale formulations for the encapsulation of hydrophobic or hydrophilic therapeutics are described.

Tags

Keywords: Flash NanoprecipitationIFNPInverse Flash NanoprecipitationPolymeric NanoparticlesHydrophobic CompoundsHydrophilic CompoundsCIJ MixerSyringe PumpsAnti-solventQuench BathVitamin EBlock Copolymer Stabilizer

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