Scalable Nanocomposite Production

Scalable nanocomposite production is the translation of nanocomposite fabrication from small laboratory batches to consistent, high-volume manufacturing, an important step for bringing advanced bioengineering materials into practical use. The process combines a polymer or other matrix with nanoscale components through controlled dispersion, mixing, and processing conditions that limit particle aggregation while preserving uniform composition and performance. Scalable methods can support the manufacture of biomaterials, tissue-engineering scaffolds, drug-delivery systems, biosensors, and medical devices with improved mechanical, electrical, barrier, or biological properties. Reliable scale-up also enables process reproducibility, quality control, and more efficient evaluation of nanocomposites for research and clinical applications.

Scalable Nanocomposite Production - Related Videos

Research

JoVE Journal - Bioengineering

Generation of Scalable, Metallic High-Aspect Ratio Nanocomposites in a Biological Liquid Medium

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Cited by 13 •

2015

Here we present a protocol to synthesize novel, high-aspect ratio biocomposites under biological conditions and in liquid media. The biocomposites scale from nanometers to micrometers in diameter and length, respectively. Copper nanoparticles (CNPs) and copper sulfate combined with cystine are the key components for the synthesis.

Research

JoVE Journal - Developmental Biology
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Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System

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Cited by 23 •

2015

The protocols described allow laboratories to perform scalable, adherent stem cell culture in high throughput with minimal labor, experience and equipment investment cost using a programmable liquid handling robot and 96-well plates. iPSCs passaged more than 20 times on this system maintained pluripotency, normal karyotypes and differentiated into cardiomyocytes.

Scalable Step-by-Step Approach of Sustainable Bioplastic Production from Food Waste

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2025

This protocol presents a scalable method for converting food waste into biodegradable polyhydroxyalkanoate (PHA) bioplastics. It utilizes arrested anaerobic digestion for food waste pretreatment, halophilic microbial fermentation for PHA biosynthesis, and a chemical-free downstream process for PHA recovery.

Preparation of Monodomain Liquid Crystal Elastomers and Liquid Crystal Elastomer Nanocomposites

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Cited by 7 •

2016

We demonstrate the preparation of siloxane-based and epoxy-based liquid crystal elastomers (LCEs) and LCE nanocomposites. The LCEs are characterized with respect to reversible strain, liquid crystal ordering, and stiffness. As a potential application, we demonstrate their use as shape-responsive substrates in a custom device for active cell culture.

Research

JoVE Journal - Chemistry
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Manufacturing of Three-dimensionally Microstructured Nanocomposites through Microfluidic Infiltration

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Cited by 4 •

2014

Three-dimensional (3D) microstructured composite beams are fabricated through the directed and localized infiltration of nanocomposites into 3D porous microfluidic networks. The flexibility of this manufacturing method enables the utilization of different thermosetting materials and nanofillers in order to achieve a variety of functional 3D reinforced nanocomposite macroscopic products.

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