Bronchial Secretion Clearance
Bronchial Secretion Clearance - Related Videos
14:39
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Cited by 4 •
2010
Bronchial thermoplasty is a non-drug procedure for severe persistent asthma that delivers thermal energy to the airway wall in a precisely controlled manner to reduce excessive airway smooth muscle. Reducing airway smooth muscle decreases the ability of the airways to constrict, thereby reducing the frequency of asthma attacks.
14:32
Primary Human Bronchial Epithelial Cells Grown from Explants
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Cited by 19 •
2010
Here we describe a detailed method for growing primary human bronchial epithelial cells from explants of human bronchial airway tissue including differentiated growth on an air-liquid interface. This method provides an abundant source of primary cells for investigating the role of the airway epithelium in human lung health and disease.
01:23
The Bronchial Tree
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2025
The human bronchi and bronchial tree play a crucial role in the respiratory system, facilitating the exchange of oxygen and carbon dioxide. Let's delve into the intricate structure and functions of these respiratory components. The trachea, commonly known as the windpipe, is a tube that connects the larynx (voice box) to the bronchi. At a point called the carina, it bifurcates into two primary bronchi. The right primary bronchus is wider, shorter, and more vertical than the left primary...
01:09
Hepatic Drug Clearance: Restrictive and Nonrestrictive Clearance
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2025
Hepatic clearance refers to the volume of blood cleared of a drug by the liver per unit of time. It plays a crucial role in drug metabolism and elimination. While hepatic clearance is commonly estimated by subtracting renal clearance from total body clearance, other pathways, such as pulmonary or biliary clearance, may also contribute. However, these pathways are generally less significant than hepatic and renal clearance. Most drugs undergo restrictive clearance, which is proportional to the...
09:12
Optimal Lentivirus Production and Cell Culture Conditions Necessary to Successfully Transduce Primary Human Bronchial Epithelial Cells
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Cited by 13 •
2016
Primary human bronchial epithelial cells are difficult to transduce. This protocol describes the production of lentiviruses and their concentration as well as the optimal culture conditions necessary to achieve highly efficient transductions in these cells throughout differentiation to a pseudostratified epithelium.
FAQs
Ciliated epithelial cells create coordinated mucociliary transport by moving mucus from smaller bronchial airways toward larger airways. This directional movement brings secretions to a location where coughing or an assisted airway-clearance technique can remove them. When transport remains effective, it helps preserve airway patency and supports ventilation by limiting the accumulation of material within the bronchial passages.
Hydration and appropriate airflow help preserve the mobility of bronchial mucus, allowing coordinated ciliary movement and subsequent expulsion to work more effectively. If secretions become less mobile, they may be harder to move toward larger airways for removal. Supporting these conditions is therefore relevant when respiratory care aims to reduce secretion retention and maintain airway patency.
Mucociliary transport moves secretions toward the larger airways, but an effective cough or assisted technique is needed to expel them. These processes therefore perform complementary roles rather than interchangeable ones. Transport positions mucus for removal, while coughing provides the final clearance action, helping prevent retained secretions from contributing to airway obstruction and impaired ventilation.
Clinical approaches include directed coughing, chest physiotherapy, postural drainage, and mechanical devices. Each can support the movement or expulsion of excessive or retained secretions when normal clearance is insufficient. The available options allow respiratory care to be individualized, with the choice guided by the need to maintain airway patency, support ventilation, and address secretion retention.
Assisted techniques may be considered when patients have excessive or retained bronchial secretions that are not being cleared adequately. Directed coughing, chest physiotherapy, postural drainage, or mechanical devices can then supplement normal mucociliary transport. Their clinical relevance lies in reducing airway obstruction and supporting gas exchange while helping prevent complications associated with persistent secretion retention.
The main clinical outcomes relate to whether secretions are being removed and whether airway function is supported. Clinicians can consider airway patency, ventilation, reduction of airway obstruction, and improvement in gas exchange. These outcomes connect the immediate clearance effort with broader respiratory health and help inform individualized care when secretions remain excessive or retained.