Proctocolectomy

Proctocolectomy is a surgical procedure that removes the entire colon and rectum, providing definitive treatment for severe or extensive disease affecting these organs. By eliminating diseased bowel, the operation prevents the colon and rectum from continuing to drive inflammation, bleeding, obstruction, or cancer risk; intestinal continuity may be restored with an ileal pouch-anal anastomosis, or stool may be diverted through an ileostomy. Clinicians use proctocolectomy for conditions such as medically refractory ulcerative colitis, familial adenomatous polyposis, and selected colorectal cancers. Its outcomes depend on disease status, reconstruction strategy, and postoperative management.

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Research

JoVE Journal - Medicine

A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium

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2024

This protocol describes the method for establishing a rat model of pouchitis. The ileal pouch model was created by performing ileal pouch-anal anastomosis (IPAA) surgery using microsurgical techniques. After the surgery, the rat was treated with 4% dextran sulfate sodium (DSS) for 4 days.

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