Telencephalon Injury
Telencephalon Injury - Related Videos
04:47
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This video demonstrates a protocol for isolating and culturing primary cerebral cortex cells from the dorsolateral telencephalon of mouse embryos.
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To shed light on the cellular and molecular mechanisms of zebrafish adult neurogenesis and regeneration, we developed a protocol for invasive surgery causing mechanical injuries in the zebrafish adult telencephalon and subsequent monitoring of changes in the stabbed hemisphere by immunohistochemistry or in situ hybridization.
07:28
Controlled Cervical Laceration Injury in Mice
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Cited by 17 •
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A novel technique to create a reproducible in vivo model of cervical spinal cord laceration injury in the mouse is described. This technique is based on spine stabilization by fixation of the cervical facets and laceration of the spinal cord using an oscillating blade with an accuracy of ±0.01 mm.
04:19
A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury
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Cited by 16 •
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06:02
Electroporation Method for In Vivo Delivery of Plasmid DNA in the Adult Zebrafish Telencephalon
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Cited by 3 •
2019
Presented here is an electroporation method for plasmid DNA delivery and ependymoglial cell labeling in the adult zebrafish telencephalon. This protocol is a quick and efficient method to visualize and trace individual ependymoglial cells and opens up new possibilities to apply electroporation to a broad range of genetic manipulations.
FAQs
Damage can alter development at several linked stages rather than producing a single defect. It may reduce neural progenitor proliferation, change how neurons migrate, or disrupt differentiation into specialized cell types. Because these processes occur sequentially, an early disturbance can influence later circuit formation and help explain broader structural and functional consequences.
Neural progenitors are important because they supply cells needed for continued tissue development. Injury that affects their proliferation can change the cellular resources available for later stages, while disrupted migration may leave neurons in inappropriate locations. Examining both processes allows developmental biologists to distinguish impaired cell production from abnormal tissue organization.
Cell death and inflammation add secondary biological responses to the initial tissue damage. Their activation can further alter the developmental environment in which surviving progenitors and neurons function. Studying these responses alongside proliferation, migration, and differentiation helps researchers determine whether abnormal outcomes reflect direct injury, secondary damage, or interference with signals that support developing neural circuits.
Experimental models are used to connect an injury event with measurable developmental changes. Researchers can examine how the developing telencephalon responds at cellular and tissue levels, then relate those findings to later alterations in brain structure or function. This approach makes it possible to investigate mechanisms without treating all early-life brain damage as biologically identical.
Relevant outcomes include changes in tissue structure, cellular behavior, and the formation of neural circuits. At the functional level, studies can ask whether early cellular disruption is associated with later changes in brain function. Considering these levels together is valuable because a visible structural alteration may reflect several underlying developmental processes rather than one isolated event.
By identifying how injury affects progenitor activity, neuronal development, cell survival, inflammation, and circuit formation, researchers can define biological processes that might be protected or supported. Experimental models also provide a setting for examining regenerative responses. In developmental biology, this work informs efforts to improve recovery after prenatal or early-life brain damage.