Biodegradable Biomaterial
Biodegradable Biomaterial - Related Videos
07:44
Overview of Biomaterials
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2023
Biomaterials are materials engineered to interact favorably with biological organisms or molecules. These materials can be derived from or produced by an organism, or can even be a synthesized polymer. Engineers use these novel materials in a wide range of applications, such as tissue engineering, biosensing and drug delivery. This video introduces common biologically derived materials, and provides examples of common techniques used to process them. Key challenges in the field are discussed,...
07:58
Electrospinning of Silk Biomaterials
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2023
Silk fibers have been processed and used to create fabrics and threads for centuries. However, the solubilizing of silk fibers, thereby turning it into a versatile pre-polymer solution is a much newer technology. Solubilized silk can be processed in many different ways to create a biocompatible material with controllable mechanical properties. This video introduces the processing of silk from silk worm cocoons, and shows how the silk solution can be used to create a fiber mat via...
09:06
Intra-lymph Node Injection of Biodegradable Polymer Particles
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Cited by 45 •
2014
Lymph nodes are the immunological tissues that orchestrate immune response and are a critical target for vaccines. Biomaterials have been employed to better target lymph nodes and to control delivery of antigens or adjuvants. This paper describes a technique combining these ideas to inject biocompatible polymer particles into lymph nodes.
02:39
Fluorescence Imaging of Biomaterial-Associated Bacterial Infection in Zebrafish Embryos
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2025
Source: Zhang, X., et al. A Zebrafish Embryo Model for In Vivo Visualization and Intravital Analysis of Biomaterial-associated Staphylococcus aureus Infection. J. Vis. Exp. (2019)This video demonstrates fluorescence imaging of zebrafish embryos injected with Staphylococcus aureus, enabling quantification of infection progression and bacterial distribution to assess the impact of biomaterial microspheres on host-pathogen interactions in vivo.
09:01
Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles
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Cited by 13 •
2013
We describe the method of programming stem cells to overexpress therapeutic factors for angiogenesis using biodegradable polymeric nanoparticles. Processes described include polymer synthesis, transfecting adipose-derived stem cells in vitro, and validating the efficacy of programmed stem cells to promote angiogenesis in a murine hindlimb ischemia model.
FAQs
These mechanisms attack the material through different pathways. Hydrolysis uses reactions involving water, enzymatic activity relies on biological catalysts, and microbial action depends on organisms processing the material. The dominant pathway affects where degradation can occur and how quickly material loss proceeds. Identifying the relevant mechanism helps engineers select compositions for biomedical devices or environmental technologies.
Chemical composition, molecular structure, porosity, and surface area all influence how rapidly a biodegradable biomaterial loses mass. These properties affect how readily water, enzymes, or microorganisms can reach and alter the material. Engineers therefore evaluate them together rather than treating degradation as a fixed characteristic. Adjusting these variables can help align material persistence with its intended temporary function.
A scaffold must remain functional while the surrounding tissue develops, so its degradation kinetics should correspond to the pace of tissue growth. If material loss and tissue development are poorly matched, the temporary structure may persist longer than needed or disappear before its role is complete. This design relationship supports tissue-engineering goals while reducing the need for later removal procedures.
Their planned breakdown allows a device or structure to perform a temporary role without necessarily remaining permanently in place. In biomedical engineering, this can limit secondary procedures associated with removing temporary implants or other supports. In environmental technologies, designing materials for eventual processing by the environment can reduce persistent waste, provided degradation behavior matches the intended use.
Engineers first identify the required temporary function, then consider whether a natural or synthetic material is appropriate. They evaluate chemical composition, molecular structure, porosity, and surface area because these characteristics influence degradation. Finally, they seek a degradation rate compatible with tissue growth or product use. This process connects material selection with the desired functional lifetime and outcome.
Biomedical applications include tissue scaffolds, resorbable sutures, drug-delivery systems, and temporary implants. Each use depends on maintaining function for an appropriate period before material loss becomes desirable. The same design principles also support sustainable environmental technologies, where degradation behavior is considered alongside product use. These applications illustrate how controlled material persistence can address both clinical and waste-related objectives.