Capillary Depression
Capillary Depression - Related Videos
08:50
Capillary Electrophoresis (CE)
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2023
Source: Laboratory of Dr. B. Jill Venton - University of Virginia Capillary electrophoresis (CE) is a separation technique that separates molecules in an electric field according to size and charge. CE is performed in a small glass tube called a capillary that is filled with an electrolyte solution. Analytes are separated due to differences in electrophoretic mobility, which varies with charge, solvent viscosity, and size. Traditional electrophoresis in gels is limited in the amount of voltage...
01:05
Long-term Depression
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2019
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory. Calcium Ion Concentration Mechanism If over time, all...
14:53
Capillary Electrophoresis Separation of Monoclonal Antibody Isoforms Using a Neutral Capillary
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Cited by 2 •
2017
Here, we present a comprehensive capillary zone electrophoresis protocol for the assessment of intrinsic physicochemical heterogeneity of monoclonal antibodies as a quality attribute.
03:12
Freezing Point Depression and Boiling Point Elevation
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2020
Boiling Point Elevation The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
03:45
Purifying Capillaries From a Porcine Brain
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2025
This video demonstrates the isolation of capillaries from fresh porcine brains. The process involves removing the meninges, isolating the grey matter from the brain tissue, homogenizing and filtering the grey matter to isolate the capillaries, and finally using enzymatic digestion to purify the capillaries further.
FAQs
The direction depends on which interaction dominates at the liquid-solid boundary. When cohesion within the liquid exceeds adhesion to the surrounding solid, the liquid does not spread readily across the surface. This force balance produces a contact angle above 90 degrees, establishing the downward-curving meniscus associated with capillary depression.
Surface tension acts along the curved liquid surface and maintains the meniscus shape. In capillary depression, the downward curvature produces a pressure difference across that interface, so the liquid level inside the narrow passage differs from the surrounding level. This pressure effect links the visible surface displacement to the fluid mechanics of small-scale systems.
The contact angle indicates how the liquid interacts with the solid boundary. Values greater than 90 degrees identify the wetting condition associated with a depressed meniscus, while changes in surface properties can alter that angle and therefore the liquid configuration. Measuring or accounting for this condition helps engineers interpret liquid transport through confined or porous spaces.
Engineers should consider the liquid's wetting behavior, the solid surface properties, and the dimensions of the tube or passage. Adhesive and cohesive forces establish the contact angle, while surface tension and passage geometry influence the resulting level and pressure difference. Considering these variables together helps predict performance in small channels and porous structures.
In narrow channels, the liquid surface and pressure distribution can differ substantially from those in surrounding fluid because surface effects act across a confined passage. Engineers account for wetting, surface properties, and channel dimensions when interpreting liquid transport. This analysis supports evaluation of how fluids behave and how small-channel systems perform.
The phenomenon provides a way to interpret liquid behavior wherever fluids occupy small passages or spaces. In porous materials and soil, it helps relate wetting and surface interactions to liquid movement. In measurement devices, the depressed level and associated pressure difference can affect how liquid conditions are read, making surface and geometry important design considerations.