Plasmonic Nanostructure Chip
Plasmonic Nanostructure Chip - Related Videos
09:29
Utilization of Plasmonic and Photonic Crystal Nanostructures for Enhanced Micro- and Nanoparticle Manipulation
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2011
Plasmonic tweezers and photonic crystal nanostructures are shown to produce useful enhancements in the efficiency and orientation control of optically trapping micro- and nano-particles.
05:21
Surface Plasmon Resonance to Study Biomolecular Interactions Using a Sensor Chip
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2025
This video describes the surface plasmon resonance, or SPR, technique for studying the interaction between two molecules using a sensor chip. The change in resonance angle and the intensity of the reflected light are detected as a function of the association and dissociation of two molecules, and this provides information about the interactions between the two molecules.
05:00
Localized Surface Plasmon Resonance Imaging to Detect Protein Secretions from a Single Cell
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2025
This video demonstrates localized surface plasmon resonance imaging to detect protein secretions from a single cell. Using a microfluidic setup and a peptide-bound plasmonic nanostructure chip, changes in reflected light intensity at the resonance angle reveal interactions with secreted proteins from a single cell.
09:12
Colloidal Synthesis of Nanopatch Antennas for Applications in Plasmonics and Nanophotonics
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Cited by 14 •
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06:58
Surface Plasmon Resonance (SPR)
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2023
Surface plasmon resonance (SPR) is the underlying optical phenomenon behind label-free biosensors to evaluate the molecular affinity, kinetics, specificity, and concentration of biomolecules. In SPR, biomolecular interactions occur on a biosensor made of a thin layer of metal on a prism. Real-time interactions of biomolecules can be monitored by measuring the changes of light reflected off the underside of the metal. This video describes the basic concepts of SPR and how it is used to analyze...
FAQs
Metallic nanofeatures enhance sensing by concentrating incident light into intense electromagnetic fields near their surfaces. A binding event occurring in this localized region therefore produces a strong optical response from a very small interfacial volume. This concentration mechanism helps the chip detect biological interactions with high sensitivity, including recognition events involving pathogen-associated molecules.
Binding changes the local refractive index at the nanostructured surface, and that change shifts the chip’s plasmonic optical response. The measurement can therefore report target capture through an optical shift rather than a fluorescent or enzymatic tag. This label-free behavior simplifies interpretation of direct molecular or pathogen-associated binding events.
Target choice determines what biological interaction the assay interrogates. Antibodies and antigens can support measurements of immune recognition, while nucleic acids or whole pathogens can indicate the presence of infection-related material or organisms. Selecting among these target classes lets investigators adapt the same chip concept to pathogen detection, biomarker measurement, or studies of host-pathogen recognition.
High sensitivity and compact format are especially relevant when sample volume is limited. Concentrated electromagnetic fields strengthen the optical consequence of binding at the nanostructured surface, while the chip format supports a small-scale measurement platform. In infection research, these properties can help move detection toward rapid screening and point-of-care settings without requiring a large specimen.
A practical workflow links surface capture to optical readout. A chip presents a nanostructured surface capable of binding an antibody, antigen, nucleic acid, or whole pathogen. The resulting interaction changes the local refractive index, and the instrument records the associated plasmonic response. Because the readout is label-free, detection focuses on the binding-induced optical shift.
In immunology and infection studies, the platform can be directed toward pathogen-associated molecules, immune biomarkers, and antibody interactions. These targets cover both sides of host-pathogen biology: evidence associated with the infectious agent and molecular interactions produced by the immune response. The resulting measurements can support pathogen screening while also helping examine how antibodies recognize relevant biological targets.
Researchers may favor this approach when rapid, small-sample analysis is important, such as pathogen screening or point-of-care diagnostic development. It is also useful when the goal is to study host-pathogen recognition or antibody interactions rather than merely establish that an organism is present. Thus, the same optical platform can serve translational and mechanistic studies.
A measured shift is interpreted as evidence that binding has altered the local refractive environment at the chip surface. Its biological meaning depends on the target presented: it may correspond to pathogen-associated material, an immune biomarker, or an antibody interaction. This connects the optical readout to specific questions about infection detection and host-pathogen recognition.